摘要
目的观察玻璃体注射康柏西普治疗视网膜中央静脉阻塞(CRVO)继发性黄斑水肿一年的疗效。设计回顾性系列病例。研究对象CRVO继发性黄斑水肿患者27例27眼。方法患者接受每月玻璃体注射康柏西普0.5 mg,连续3个月;其后每月随访按需注射至12个月(3+PRN)。治疗前及随访时检测患眼最佳矫正视力(BCVA)、BCVA提高三行者的百分比,相干光断层扫描(OCT)检测中心视网膜厚度(CRT),记录一年总注射次数及安全性。主要指标BCVA、CRT。结果治疗后第3及第12个月,患者平均BCVA较治疗前分别提高(12.7±7.6)及(14.8±9.6)个EDTRS字母;平均CRT分别减少(374.5±280.7)μm及(428.2±241.3)μm;BCVA提高3行患者的百分比分别为45.1%及52.9%。一年平均总注射次数为(7.6±1.5)针。未发现局部及全身严重不良反应。结论采用3+PRN策略进行玻璃体注射康柏西普治疗CRVO继发性黄斑水肿,随访一年证实安全有效。
Objective To evaluate the 1-year follow-up efficacy of intravitreal injection of Conbercept for treatment of macular edema secondary to central retinal vein occlusion(CRVO).Design Retrospective case series.Participant Twenty-seven eyes in 27 patients with macular edema associated with CRVO were retrospectively reviewed.Methods The CRVO eyes received monthly intravitreal injection of Conbercept(0.5 mg)for 3 months.From then on,the patients were followed up monthly and received PRN injection up to 12 months.Main Outcome Measures Best-corrected visual acuity(BCVA),central retinal thickness(CRT),proportion of patients gaining≥15 EDTRS letters,the number of total injections in one-year and safty.Results The mean BCVA gain from baseline was 12.7±7.6 letters at month 3 and 14.8±9.6 letters at month 12.The mean CRT reduction from baseline was(374.5±280.7)μm at month 3 and(428.2±241.3)μm at month 12.The proportion of patients who gained≥15 letters in BCVA was 45.1%at month 3 and 52.9%at month 12.The mean number of injections was 7.6±1.5.No severe local and systemic complications occurred following injection.Conclusion Intravitreal injection of Conbercept by 3+PRN regime was safe and efficacious for treatment of patients with macular edema secondary to CRVO through one-year follow-up.
作者
曾惠阳
李晓霞
刘谦
肖媛媛
候思梦
ZENG Hui-yang;LI Xiao-xia;LIU Qian;XIAO Yuan-yuan;HOU Si-meng(Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing Tongren Hospital,Capital Medical University,Beijing 100005,China)
出处
《眼科》
CAS
2019年第4期254-258,共5页
Ophthalmology in China
