摘要
以6-芳基咪唑并[2,1-b]噻唑并苯等底物与氟虫腈类似物二硫醚为起始原料,探索合成具有潜在生物活性的亚磺酰基咪唑杂环化合物。研究表明,在乙醇介质中,60℃,用I2/H2O2催化氧化,合成产物的产率高,区域选择性好,用时少。通过红外光谱、核磁共振氢谱、核磁共振碳谱、X-单晶衍射仪、高效液质联用仪等分析方法对合成产物的结构进行了表征,证明了合成方法的可靠性。
The synthetic method of sulfonyl imidazoheterocycles with potential biological activities using the substances of 6-aryl imidazo[2,1-b]thiazolyl benzo and the fipronil analogues disulfide was explored. The study indicated that imidazoheteracycles underwent efficient and regioselective sulfenylation with fipronil analogues disulfide using the iodine/hydrogen peroxide system in ethanol at 60 ℃ just few hours. All the compounds were characterized by IR,1HNMR,13CNMR,single X-ray crystal diffraction analysis and HRMS(ESI) analysis,proving the reliability of the synthesis.
作者
李术艳
姚玉彬
LI Shu-yan;YAO Yu-bin(Zhangzhou Institute of Technology, Fujian Zhangzhou 363000, China)
出处
《广州化工》
CAS
2019年第15期46-48,68,共4页
GuangZhou Chemical Industry
基金
福建省教育厅中青年教师教育科研项目(JZ180815)
福建省科技计划项目:漳州市食品产业技术研究院建设(2018N2002)
