摘要
目的探讨肾康注射液治疗老年糖尿病肾病的疗效和安全性,为明确有效治疗老年糖尿病肾病的方法提供方法。方法选择2016年11月—2018年11月在武汉市中心医院肾内与风湿科治疗的老年糖尿病肾病患者112例,采用数字表法随机分为观察组(n=56)和对照组(n=56)。对照组给予常规治疗,观察组在与对照组相同的常规治疗基础上增加肾康注射液治疗,疗程均为28 d。评估并比较2组治疗前后肾功能水平、血糖水平、中医症状积分、临床疗效以及不良反应发生情况。结果治疗前,2组肌酐(Creatinine,Scr)、尿素氮(Blood urea nitrogen,BUN)、24 h尿蛋白、肌酐清除率(Creatinine clearance,Ccr)水平差异均无统计学意义(P>0.05)。治疗后,2组Scr、BUN、24 h尿蛋白水平均比治疗前显著下降,且观察组水平显著低于对照组,差异均有统计学意义(P<0.05)。治疗前,2组空腹血糖、血红蛋白(Hemoglobin,Hb)、白蛋白(Albumin,Alb)和血钙(Calcium,Ca)水平差异均无统计学意义(P>0.05)。治疗后,2组空腹血糖比治疗前均显著下降,且观察组水平显著低于对照组,差异均有统计学意义(P<0.05);Hb、Alb和Ca水平比治疗前均升高,且观察组患者Hb和Alb水平显著高于对照组,差异均有统计学意义(P<0.05)。治疗前,2组中医症状积分无显著差异(P>0.05)。治疗后,2组中医症状积分比治疗前均降低,且观察组积分显著低于对照组,差异均有统计学意义(P<0.05)。治疗结束后,观察组临床有效率显著高于对照组[96.43%(54/56)vs 73.21%(41/56),P<0.05)]。2组均未出现明显的不良反应。结论在常规西医治疗的基础上采用肾康注射液治疗老年糖尿病肾病,可显著改善患者的肾功能、血糖水平,显著提高临床疗效,且安全性较高,具有一定的临床应用价值。
Objective To observe the effect of Shenkang Injection on diabetic nephropathy in the elderly and the safety.Methods 112 hospitalized elderly with diabetic nephropathy during the period from Nov., 2016 to Nov., 2018 were selected and were randomly divided into 2 groups: observation group and control group, 56 in each;routine treatment was given to the elderly in both groups while treatment with Shenkang Injection was added to the elderly in observation group, the course for both groups lasted for 28 days;the levels of renal function and blood glucose, the TCM symptom scores, the clinical curative effects and the adverse reactions of the elderly in the 2 groups before and after treatment were evaluated and comparatively studied. Results Before treatment, there existed no statistical difference in levels of serum creatinine(Scr), blood urea itrogen(BUN),24-hour urinary protein and creatinine clearance(Ccr) between the 2 groups(P>0.05) while after treatment, the levels of Scr, BUN and 24-hour urinary protein in both groups dropped down, much lower than those before treatment and the decrease in observation group was bigger than that in control group with a difference of statistical significance(P<0.05);before treatment,the levels of fast blood glucose, hemoglobin(Hb), albumin(Alb) and calcium(Ca) in both groups were of no statistical difference(P>0.05) while after treatment, the levels of fast blood glucose in both groups were lower than those before treatment and the level in observation group was even lower than that in control group with statistical difference(P<0.05);the levels of Hb, Alb and Ca in both groups were higher after treatment than those before treatment and the levels of Hb and Alb in observation group after treatment were much higher than those in control group(P<0.05);after treatment, the TCM symptom scores in the2 groups decreased, lower than those before treatment and the scores in observation group were much lower than those in control group after treatment(P<0.05);the clinical effective rate in
作者
李莉
孟晶
黎姣
Li Li;Meng Jing;Li Jiao(Department of Nephrology and Rheumatism, Wuhan Central Hospital, Wuhan, Hubei Province, 430014, P. R. China)
出处
《老年医学与保健》
CAS
2019年第4期511-513,522,共4页
Geriatrics & Health Care
关键词
老年
糖尿病肾病
肾康注射液
疗效
安全性
elderly
diabetic nephropathy
Shenkang Injection
curative effect
safety
