摘要
目的:探讨基于MR图像的纹理分析技术在颅内纤维性肿瘤/血管周细胞瘤(SFT/HPC)与血管瘤型脑膜瘤(AM)的术前鉴别诊断中的临床应用价值。方法:回顾性分析经手术及病理确诊的24例SFT/HPC患者和20例AM患者的临床资料及术前MRI资料。利用ImageJ软件在T2WI、对比增强T1WI(T1CE)和ADC图像中选取肿瘤最大径层面并在瘤体实性部分勾画ROI,采用直方图和灰度共生矩阵(GLCM)两种纹理分析方法,测量病灶的最大值、最小值、均值、中位数、标准差、峰度、偏度、角二阶矩(ASM)、对比度、逆差矩、熵值及自相关等纹理参数,并采用两独立样本t检验和Mann-WhitneyU检验比较SFT/HPC与AM的各项纹理参数的差异,对有统计学意义的参数绘制受试者工作特征(ROC)曲线,分析其对SFT/HPC及AM的鉴别诊断效能。结果:①直方图参数中,在T2WI、T1CE和ADC图像上SFT/HPC的最大值(MaxT2WI、MaxT1CE)、最小值(MinT2WI、MinT1CE、MinADC)、均值(MeanT2WI、MeanT1CE、MeanADC)和中位数(MedT2WI、MedT1CE、MedADC)均低于AM,在T1CE图像上的标准差(SDT1CE)大于AM,在T2WI和T1CE图像上的峰度值(KurtT2WI、KurtT1CE)和偏度值(SkeT2WI、SkeT1CE)均大于AM,组间差异均有统计学意义(P<0.05)。②在GLCM参数中,SFT/HPC在ADC图像上的ASM值(ASMADC)小于AM,在T2WI和T1CE图像上的对比度(ConT2WI、ConT1CE)小于AM,在ADC图像上的熵值(EntADC)大于AM,组间差异均有统计学意义(P<0.05);在T2WI、T1CE和ADC图像上的逆差矩值(IDMT2WI、IDMT1CE、IDMADC)及T1CE图像上的自相关值(CorT1CE)的组间差异均有统计学意义(P<0.05);③在AUC>0.7的参数中,以MinT1CE、MedT1CE和MeanT1CE的诊断效能最佳,AUC(敏感度、特异度)分别为0.970(95.8%、90.0%)、0.964(91.7%、95.0%)和0.960(91.7%、95.0%)。结论:MRI的纹理分析可提供更多量化信息,对于术前通过MRI鉴别SFT/HPC与AM有着重要的临床意义。
Objective:To explore the clinical value of preoperative MRI image texture analysis in distinguishing solitary fibrous tumors/hemangiopericytoma(SFT/HPC)and angiomatous meningioma(AM).Methods:The clinical data and preoperative magnetic resonance imaging data of 32 patients with SFT/HPC and 24 patients with AM confirmed by operation and pathology were retrospectively analyzed.All patients underwent T 2WI,DWI and contrast-enhanced T 1WI(T 1CE).The texture parameters,including maximum value,minimum value,average value,median,standard deviation(SD),skewness,kurtosis,angular second moment,contrast,inverse different moment,entropy and correlation were measured using histograms and grey-level co-occurrence matrix(GLCM)and compared between SFT/HPCs and AMs.The independent sample t test or the Mann-Whitney U test was used for data procession and analysis.ROC curves for statistically significant parameters were used to analyse their efficacy in predicting SFT/HPC and AM.Results:①In histogram parameters,the maximum values(Max T 2WI,Max T 1CE),minimum values(Min T 2WI,Min T 1CE,Min ADC),mean values(Mean T 2WI,Mean T 1CE,Mean ADC),and medians(Med T 2WI,Med T 1CE,Med ADC)of SFT/HPCs measured on T 2WI,T 1CE,and ADC images were smaller than those of AM;and the kurtosis values(Kurt T 2WI,Kurt T 1CE)and skewness values(Ske T 2WI,Ske T 1CE)of SFT/HPCs measured on T 2WI and T 1CE were all greater than those of AMs,and the difference was statistically significant(P<0.05).②In GLCM parameters,the ASM energy value(ASM ADC)measured on ADC images,and the contrast values(Con T 2WI,Con T 1CE)measured on T 2WI and T 1CE of SFT/HPCs were smaller than those of AM;and the entropy values(Ent ADC)of SFT/HPCs on ADC images were greater than that of AMs,and the difference was statistically significant.The inverse moment values on T 2WI,T 1CE and ADC images(IDM T 2WI,IDM T 1CE,IDM ADC)and the autocorrelation values on T 1CE(Cor T 1CE)were statistically different between the two groups(all P<0.05);③For the texture parameters with statistical dif
作者
张烁
程敬亮
王程程
张勇
ZHANG Shuo;CHENG Jing-liang;WANG Cheng-cheng(Department of MRI,the First Affiliated Hospital of Zhengzhou University,Zhenzhou 450052,China)
出处
《放射学实践》
北大核心
2019年第8期841-846,共6页
Radiologic Practice
关键词
血管周细胞瘤
纤维性肿瘤
脑膜瘤
血管瘤型
纹理分析
磁共振成像
Solitary fibrous tumors/Hemangiopericytoma
Angiomatous meningioma
Texture analysis
Magnetic resonance imaging
