摘要
神经细胞尤其是多巴胺能神经元的程序性死亡是帕金森病(PD)的主要病理改变,涉及细胞凋亡、自噬样细胞死亡、细胞坏死等多种类型。百草枯能选择性地破坏黑质纹状体系统,诱发神经细胞的程序性死亡,导致PD。百草枯致PD的机制包括细胞凋亡和神经元自噬的过度激活以及星形胶质细胞的自噬障碍,可导致病理性蛋白聚集和清除障碍以及细胞坏死死亡通路的异常。百草枯暴露导致PD神经细胞程序性死亡的机制复杂,目前具体机制尚不清楚。
The programmed death of neurons,especially dopaminergic neurons,is the main pathological change of Parkinson′s disease(PD),involving apoptosis,autophagic cell death,cell necrosis and other types.Paraquat can selectively destroy the substantia nigra striatum system and induce programmed neuronal death,leading to PD.The mechanisms of paraquat-induced PD include excessive activation of apoptosis and autophagy of neurons and autophagy disorder of astrocytes,which can lead to pathological protein aggregation/clearance disorders and abnormal necrosis and death pathways.The mechanism of programmed death of PD neurons caused by paraquat exposure is complex,and the specific mechanism is still unclear.
作者
商跃云
张慧
SHANG Yueyun;ZHANG Hui(Emergency Department,Tianjin Children′s Hospital,Tianjin 300134,China)
出处
《医学综述》
2019年第15期3065-3070,共6页
Medical Recapitulate
关键词
帕金森病
百草枯
程序性细胞死亡
Parkinson′s disease
Paraquat
Programmed cell death
