摘要
目的分析七氟烷联合瑞芬太尼对重度子痫前期剖宫产产妇的心血管保护作用及炎症状况的影响。方法选择2016年3月~2018年1月河北医科大学第一医院接诊的重度子痫前期剖宫产产妇80例作为研究对象,根据随机数字表法分为两组,每组40例。对照组单纯给予瑞芬太尼进行麻醉,观察组给予七氟烷联合瑞芬太尼进行麻醉。观察两组产妇不同时间的收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、心率(HR)、中心静脉压(CVP)、每搏指数量(SV)、心排出量(CO)等血流动力学指标及C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)等炎症状况指标,记录两组产妇麻醉不良反应的发生情况。结果两组麻醉前血流动力学指标水平比较,差异无统计学意义(P>0.05);两组插管后、切皮、娩出、缝合、拔管时血流动力学指标水平比较,差异有统计学意义(P<0.05);两组诱导后SBP、DBP水平比较,差异有统计学意义(P<0.05);两组组内不同时间的血流动力学指标水平比较,差异有统计学意义(P<0.05)。两组产妇麻醉前炎症状况指标水平比较差异无统计学意义(P>0.05);两组拔管、术后6h、术后24h炎症状况指标水平比较,差异有统计学意义(P<0.05);两组组内不同时间的炎症状况指标水平比较,差异有统计学意义(P<0.05)。观察组麻醉不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论七氟烷联合瑞芬太尼可维持产妇血流动力学的平稳,保持重要器官的正常灌注,维持机体的稳态,减弱机体的炎性反应,值得临床推广应用。
Objective To analyze the effect of Sevoflurane combined with Remifentanil on cardiovascular protection and inflammation in cesarean section women with severe preeclampsia.Methods Eighty cases of cesarean section women with severe preeclampsia who were admitted to the First Hospital of Hebei Medical University from March 2016 to January 2018 were selected as the study subjects.They were divided into two groups according to random number table method,40 cases in each group.The control group was given Remifentanil only for anesthesia,while the observation group was given Sevoflurane combined with Remifentanil for anesthesia.Systolic blood pressure (SBP),diastolic blood pressure (DBP),mean arterial pressure (MAP),heart rate (HR),central venous pressure (CVP),stroke index (SV),cardiac output (CO) and other hemodynamic indicators were observed in two groups at different time.Inflammatory indices such as C-reactive protein (CRP),tumor necrosis factor-α(TNF-α),interleukin-6 (IL-6) were observed in two groups at different time.The incidence of adverse reactions to anesthesia in two groups of parturients was recorded.Results There was no significant difference in hemodynamic parameters between two groups before anesthesia (P > 0.05).There were significant differences in hemodynamic indexes after intubation,skin incision,delivery,suture and extubation between two groups (P < 0.05).There were significant differences in SBP and DBP levels between two groups after induction (P < 0.05).There was significant difference in hemodynamic indexes between two groups at different time points (P < 0.05).There was no significant difference in the level of inflammation before anesthesia between two groups (P > 0.05).There was a significant difference in the levels of inflammatory indexes between two groups at 6 hours after extubation and 24 hours after operation (P < 0.05).There was a significant difference in the level of inflammatory status indicators between two groups at different time points (P < 0.05).The incidence of adverse reac
作者
陈浩
李慧利
周长浩
王欣
CHEN Hao;LI Huili;ZHOU Changhao;WANG Xin(Department of Anesthesia and Surgery,the First Hospital of Hebei Medical University,Hebei Province,Shijiazhuang 050031,China)
出处
《中国医药导报》
CAS
2019年第22期107-110,共4页
China Medical Herald
基金
河北省卫生厅科技项目(20160699)
关键词
重度子痫
剖宫产
七氟烷
瑞芬太尼
Severe preeclampsia
Cesarean section
Sevoflurane
Remifentanil
