摘要
目的探讨加味酸枣仁汤对高中生失眠症的疗效以及5-羟色胺转运体启动子区域(serotonin transporter-linked promoter region,5-HTTLPR)基因多态性与疗效的关系。方法收集失眠症高中生对照组50例和加味酸枣仁汤组47例。对照组仅调整作息时间,加味酸枣仁汤组同时给予加味酸枣仁汤1周。测定治疗前后匹兹堡睡眠质量指数(PSQI),用配对t检验比较差异。采集血液,测定5-HTTLPR基因型,用χ~2检验分析与疗效的关系。结果加味酸枣仁汤治疗后,显著降低主观睡眠质量(2.17±0.38 vs. 0.77±0.48)、入睡时间(2.11±0.37 vs. 0.68±0.52)、睡眠时间(1.43±0.50 vs. 0.89±0.37)、睡眠效率(1.51±0.51 vs. 0.87±0.40)、睡眠障碍(1.40±0.54 vs. 0.85±0.42)、日间功能障碍(1.70±0.46 vs. 0.89±0.37)以及总分(10.32±1.07 vs. 4.96±0.95),均P<0.001;该组治疗有效率72.34%(34/47)明显高于对照组6.00%(3/50),差异有统计学意义(P<0.001);显效、有效患者LL基因型频率和L等位基因频率均高于无效者(P=0.007和P<0.001)。结论加味酸枣仁汤对高中生失眠症有疗效,并受5-HTTLPR基因型影响。
Objective To evaluate the treatment effect of Jiawei Suanzaoren Decoction on insomnia of senior high school students and to identify the association between serotonin transporter-linked promoter region(5-HTTLPR) genetic polymorphism and its efficacy. Methods Senior high school students with insomnia(50 cases for the control group and 47 cases for the Jiawei Suanzaoren Decoction group) were recruited.Participants in the control group only required to adjust their rest time, and those in the Jiawei Suanzaoren Decoction group also received Jiawei Suanzaoren Decoction for 1 week. Pittsburgh Sleep Quality Index(PSQI) before and after treatment was tested and compared by paired-t test. Blood was collected for 5-HTTLPR genotype determination and their associations with different responses were analyzed by χ~2 test.Results After treatment with Jiawei Suanzaoren Decoction, the scores of subjective sleep quality(2.17±0.38 vs. 0.77±0.48), sleep latency(2.11±0.37 vs. 0.68±0.52), sleep duration(1.43±0.50 vs. 0.89±0.37),habitual sleep efficiency(1.51±0.51 vs. 0.87±0.40), sleep disturbances(1.40±0.54 vs. 0.85±0.42), daytime dysfunction(1.70±0.46 vs. 0.89±0.37), and total score(10.32±1.07 vs. 4.96±0.95) of PSQI were obviously decreased as compared those of baseline(all P<0.001). The treatment effectiveness rate in the Jiawei Suanzaoren Decoction group(72.34%,34/47) was obviously higher than that of the control group(6.00%,3/50), P<0.001. LL genotype frequency and L allele frequency in the marked effective patients and effective patients treated with Jiawei Suanzaoren Decoction were significantly increased as compared with those of the ineffective patients(P=0.007, P<0.001). Conclusion Jiawei Suanzaoren Decoction has the treatment effect on insomnia of senior high school students and 5-HTTLPR genotypes may influence its efficacy.
作者
方芳
罗伏钢
李静
邵琼琰
陈丽琼
刘义
刘文娟
胡霖霖
张永华
宋明芬
FANG Fang;LUO Fu-Gang;LI Jing(Department of Outpatient,Hangzhou Seventh People's Hospital,Hangzhou,Zhejiang 310013,China)
出处
《中华全科医学》
2019年第9期1575-1578,共4页
Chinese Journal of General Practice
基金
国家自然科学基金项目(81601183)
浙江省中医药科技项目(2018ZA101)
杭州市科技发展计划项目重点专科专病科研攻关专项(20160533B28)
浙江省博士后基金(2016年第119号)
关键词
加味酸枣仁汤
高中生
失眠症
5-羟色胺转运体启动子区域
基因多态性
Jiawei Suanzaoren Decoction
Senior high school students
Insomnia
Serotonin transporter-linked promoter region
Genetic polymorphism
