摘要
目的探讨复发性阿弗他溃疡发病群体、发病部位和治疗的方法,同时对康复新液结合臭氧的治疗效果进行讨论,分析其对唾液表皮生长因子(EGF)及血清白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)、超氧化物歧化酶(SOD)、分泌型免疫球蛋白A(SIgA)的影响。方法选取2016年1月-2018年1月杭州师范大学附属医院收治的64例复发性阿弗他溃疡患者,应用抽签法将患者随机分为2组,对照组应用臭氧治疗,研究组在对照组的基础上应用康复新液治疗。比较2组治疗前后IgG、SIgA、SOD变化、VAS评分和溃疡持续时间及血清TNF-α、IL-6水平等。结果研究组治疗后IgG和SIgA变化大于对照组(均P<0.05),研究组IgG、SIgA、SOD值分别为(23.52±6.44)g/L、(64.62±11.23)g/L、(290.26±57.33)g/L;研究组VAS评分为(2.01±0.23)分和溃疡持续时间为(3.25±0.96)d,均低于对照组(均P<0.05);研究组治疗后TNF-α、IL-6及EGF水平分别为(134.02±20.15)ng/mL、(73.23±8.73)ng/mL、(3.2±0.6)ng/mL,均低于对照组,差异具有统计学意义(均P<0.05)。结论使用康复新液结合臭氧治疗复发性阿弗他溃疡,效果理想,并且对患者受损表皮的再生和修复起到了一定的促进作用,有效改善了患者唾液EGF及血清IL-6、SOD、SIgA水平。
Objective To investigate the pathogenesis and treatment of recurrent aphthous ulcer, and to discuss the therapeutic effect of rehabilitation new fluid combined with ozone, and to discuss salivary epidermal growth factor(EGF) and serum interleukin-6. The effects of(IL-6), superoxide dismutase(SOD), and secretory immunoglobulin A(sIgA) were investigated. Methods Sixty-four patients with recurrent aphthous ulcer admitted to our hospital from January to February 2018 were randomly divided into two groups. The control group was treated with ozone. The study group was applied on the basis of the control group. Rehabilitation new fluid treatment. The changes of IgG, SIgA, SOD, VAS score, ulcer duration and serum level were compared before and after treatment. Results The changes of IgG and SIgA in the study group were significantly higher than those in the control group(all P<0.05). The IgG, SIgA and SOD values of the study group were(23.5±6.4) g/L,(64.6±11.2) g/L and(290.2±57.3) g/L, respectively. The difference was statistically significant. The VAS score(2.01±0.23) and the ulcer persistence score(3.25±0.96) were lower in the study group than in the control group(all P<0.05).The TNF-α, IL-6 and EGF indexes in the study group were respectively determined. The scores were(134.02±20.15) ng/mL,(73.23±8.73) ng/mL and(3.2±0.6) ng/mL, which were lower than the control group(all P<0.05). The difference was statistically significant. Conclusion For patients with recurrent aphthous ulcer, the treatment of rejuvenating new fluid combined with ozone is not only effective, but also promotes the regeneration and repair of damaged epidermis, effectively improving the saliva EGF of patients and serum IL-6, SOD, sIgA levels.
作者
胡旭
陈静静
HU Xu;CHEN Jing-jing(Department of Oral and Maxillofacial Surgery,Affiliated Hospital of Hangzhou Normal University,Hangzhou,Zhejiang 310015,China)
出处
《中华全科医学》
2019年第9期1512-1514,共3页
Chinese Journal of General Practice
基金
浙江省医药卫生科技计划项目(2014KYB229)
