摘要
目的:观察银杏叶片联合多奈哌齐治疗血管性痴呆(VD)患者临床疗效。方法:选取本院86例VD患者,按照随机数字表法将其分为观察组和对照组,各43例。对照组予以多奈哌齐治疗,观察组在对照组基础上予以银杏叶片治疗。对比两组临床疗效、不良反应发生率、治疗前后简易智力状态检查量表(MMSE)评分、Barthel指数评分、血液流变学指标[全血还原黏度高切、全血还原黏度低切、纤维蛋白原(Fib)]水平。结果:观察组治疗总有效率为95.35%,高于对照组的79.07%(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);治疗12周后,观察组全血还原黏度高切、全血还原黏度低切、Fib均低于对照组,MMSE、Barthel指数评分均高于对照组,差异均有统计学意义(P<0.05)。结论:银杏叶片联合多奈哌齐治疗VD患者,疗效显著,可改善患者血液流变学,增强患者认知功能,提高患者日常生活能力,且具有一定安全性。
Objective:To observe the clinical efficacy of Ginkgo Tablet combined with Donepezil in treatment of patients with vascular dementia(VD).Method:A total of 86 patients with VD in our hospital were selected.According to the random number table method,they were divided into observation group and control group,43 cases in each.The control group was treated with Donepezil,while observation group was treated with Ginkgo Tablet on the basis of control group.The clinical efficacy,incidence of adverse reactions,simple mental state examination scale(MMSE)score,Barthel index score and hemorheological index[whole blood reduced viscosity high shear,whole blood reduced viscosity low shear,fibrinogen(Fib)]levels before and after treatment between two groups were compared.Result:The total effective rate of observation group was 95.35%,which was higher than 79.07% of control group(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).After 12 weeks of treatment,the whole blood reduced viscosity high shear,whole blood reduced viscosity low shear and Fib were lower than those of control group,the scores of MMSE and Barthel index were higher than those of control group,the differences were statistically significant(P<0.05).Conclusion:Ginkgo Tablet combined with Donepezil in treatment of VD patients has a significant effect,it can improve hemorheology,cognitive function and daily living ability of patients,and has a certain degree of safety.
出处
《中国医学创新》
CAS
2019年第18期121-124,共4页
Medical Innovation of China
