摘要
炎症性肠病(IBD)是一种慢性非特异性肠道炎症性疾病,病因尚未明确。近年来,肠道菌群在IBD的发病和预后中的作用越来越被关注。粪菌移植(FMT)是将健康人肠道菌群移植至患者的胃肠道内,重建具有正常功能的肠道菌群。许多研究结果表明,FMT在IBD治疗中有效,为临床上药物治疗效果不理想的IBD患者带来希望。文章主要就FMT在IBD治疗中的应用和注意事项进行综述。
Inflammatory bowel disease(IBD)is a chronic,nonspecific,inflammatory bowel disease that has not been completely elucidated yet. In recent years,the role of gut flora in the pathogenesis and prognosis of IBD has drawn more and more attention. Fecal Bacterial Transplantation(FMT)referred to transplanting healthy human gut flora into the patient's gastrointestinal tract and reconstitutes a functioning gut flora. Many studies have shown that FMT is effective in treatment of IBD. This brings new hope to IBD patients with poor clinical drug treatment. The applications and precautions of FMT in IBD are reviewed.
作者
王郑君
刘建强
王雯
WANG Zheng-jun;LIU Jian-qiang;WANG Wen(Department of Gastroenterology,the 900th Hospital,Fuzong Clinical Medical College of Fujian MedicalUniversity,Fuzhou 350025,Fujian,China)
出处
《医学研究生学报》
CAS
北大核心
2019年第8期891-896,共6页
Journal of Medical Postgraduates
关键词
粪菌移植
炎症性肠病
溃疡性结肠炎
艰难梭菌感染
次级胆汁酸
fecal microbiota transplantation
inflammatory bowel disease
ulcerative colitis
clostridium difficile infection
secondary bile acids
