摘要
目的探讨影响高危型人乳头瘤病毒(HPV)持续感染因素,旨在为降低高危型HPV持续感染和宫颈癌的发生提供参考依据。方法选取2015年1月—2015年12月大连市某农村35~64岁、宫颈完整且无宫颈癌病史,能理解研究程序且自愿参加HPV检测的2000例妇女完成宫颈癌筛查调查表。2017年度进行随访并且再次进行HPV筛查。结果2000例调查对象中,感染型别共有14种。其中,阳性191例(9.55%)。随访1432例调查对象,感染型别共有15种。其中,阳性151例(10.54%);141例感染高危型HPV,其中51例为持续感染高危型HPV(36.17%)。多因素Logistics回归结果显示,甲状腺疾病[Ol^R=3.500(95%CI:1.067,11.478)]和宫颈炎[Ol^R=2.721(95%CI:1.322,5.603)]是高危型HPV持续感染的危险因素。结论宫颈炎和甲状腺疾病是高危型HPV持续感染的危险因素,应采取针对性的防控措施,降低高危型HPV持续感染的发生。
Objective To investigate the factors affecting the persistent infection of high-risk HPV, and to provide a reference for reducing the incidence of high-risk HPV infection and cervical cancer. Methods A total of 2 000 women aged from 35 to 64 years in a rural area of Dalian in 2015 were selected. There was no history of cervical cancer and cervical integrity. They could understand the research procedure and volunteer to participate in HPV testing, and completed the questionnaire survey. Follow-up was performed 2 years later and HPV screening was performed again. Results In 2015, among the 2, 000 respondents, there were 14 types of infections in HPV screening. The positive number was 191, and the positive rate was 9.55%. In 2017, the follow-up was 1432, and the HPV screening results were infectious. There are 15 species in total, and the number of positive cases is 141, and the positive rate is 10.54%. Among the 1 432 follow-up subjects, 141 were infected with high-risk HPV, and 51 of them were persistently infected with high-risk HPV, and the sustained infection rate was 36.17%. Multivariate logistic regression results showed that there were significant differences in the influencing factors between cervicitis [O ^ R=3.500 (95% CI: 1.067, 11.478)] and thyroid disease [O ^ R=2.721 (95% CI: 1.322, 5.603)]. Conclusions The influencing factors of cervicitis and thyroid disease are risk factors for persistent infection of high-risk HPV. Targeted prevention and control measures should be taken to reduce the incidence of persistent high-risk HPV infection.
作者
刘明月
崔璐
李晓枫
马莉
陈欣
金星
高晓虹
Ming-yue Liu;Lu Cui;Xiao-feng Li;Li Ma;Xin Chen;Xing Jin;Xiao-hong Gao(Department of Epidemiology, School of Public Health of Dalian Medical University,Dalian, Liaoning 116044, China)
出处
《中国现代医学杂志》
CAS
2019年第16期58-63,共6页
China Journal of Modern Medicine
基金
国家卫生和计划生育委员会公益性行业科研专项(No:201502004)
关键词
人乳头瘤病毒
农村人口
感染
防御医学
papillomaviridae
rural population
infection
defense medicine
