摘要
目的分析钝性胸部创伤(BCT)所致多发性肋骨骨折或肺挫伤患者血清表面活性蛋白D(SP-D)和白介素6(IL-6)水平变化及其临床意义。方法选取2014年1月-2018年10月在南京鼓楼医院集团宿迁市人民医院胸外科住院的BCT所致多发性肋骨骨折患者106例作为A组,BCT所致肺挫伤患者106例作为B组,同期在本院体检健康者106例作为对照组。比较A组与B组患者创伤情况,并比较三组受试者6 h、24 h、7 d血清SP-D和IL-6水平。结果(1)A组与B组患者创伤原因、创伤部位、创伤严重程度(ISS)评分、其他胸部创伤情况、全身创伤情况、肺不张及肺炎发生率、住院时间比较,差异无统计学意义(P>0.05)。(2)以对照组受试者血清SP-D和IL-6水平为常模,A组、B组患者创伤后6 h、24 h、7 d血清SP-D水平高于对照组,B组患者创伤后6 h、24 h、7 d血清SP-D水平高于A组(P<0.05);A组、B组患者创伤后6 h、24 h及B组患者创伤后7 d血清IL-6水平高于对照组,B组患者创伤后6 h、24 h血清IL-6水平高于A组(P<0.05)。结论 BCT所致多发性肋骨骨折或肺挫伤患者血清SP-D和IL-6水平明显升高,创伤后24 h内检测血清SP-D和IL-6水平有助于判断BCT病情严重程度。
Objective To analyze the change and clinical significance of serum levels of SP-D and IL-6 in blunt chest trauma(BCT)patients complicated with multiple ribs fracture or pulmonary contusion.Methods From January 2014 to October 2018 in the Department of Thoracic Surgery,Suqian People’s Hospital of Nanjing Gulou Hospital Group,106 BCT patients complicated with multiple ribs fracture were selected as A group,106 BCT patients complicated with pulmonary contusion were selected as B group,meanwhile 106 healthy volunteers admitted to this hospital for physical examination were selected as control group.Trauma related indicators were compared between A group and B group,serum levels of SP-D and IL-6 were compared in the three groups 6 hours,24 hours and 7 days after trauma.Results(1)No statistically significance difference of trauma causes,trauma locations,Injury Severe Score,other thoracic trauma,whole body trauma,incidence of pulmonary atelectasis or pneumonia,or hospital stays was found between A group and B group(P>0.05).(2)Taking control group as norm,serum SP-D level in A group and B group was statistically significantly higher than that in control group6 hours,24 hours and 7 days after trauma,respectively,meanwhile serum SP-D level in B group was statistically significantly higher than that in A group 6 hours,24 hours and 7 days after trauma,respectively(P<0.05);serum IL-6 level 6 hours and 24 hours after trauma in A group and B group,serum IL-6 level 7 days after trauma in B group was statistically significantly higher than that in control group,respectively,meanwhile serum IL-6 level in B group was statistically significantly higher than that in A group 6 hours and 24 hours after trauma,respectively(P<0.05).Conclusion Serum levels of SP-D and IL-6 are significantly elevated in BCT patients complicated with multiple ribs fracture or pulmonary contusion,the detection of the above two within 24 hours after trauma is helpful to evaluate the severity of illness.
作者
戴宁凰
郑中锋
李威
陆波
庄淮千
DAI Ninghuang;ZHENG Zhongfeng;LI Wei;LU Bo;ZHUANGHuaiqian(Department of Thoracic Surgery,Suqian People's Hospital of Nanjing Gulou Hospital Group,Suqian 223800,China)
出处
《实用心脑肺血管病杂志》
2019年第7期97-99,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
江苏省卫生计生委2017年医学科研课题青年项目(Q201708)
