摘要
目的比较布地奈德模特罗粉吸入与氨茶碱片口服治疗缓解期慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的疗效及对患者血气指标、肺功能影响.方法研究对象选取海南省第三人民医院2015年5月—2017年5月间收治的缓解期COPD患者146例,按照入院ID随机分为试验组与对照组,每组各73例.对照组患者予以氨茶碱片口服治疗,试验组患者予以布地奈德福莫特罗干粉吸入治疗.比较两组患者总有效率、肺功能、血气指标、生活质量、变化呼吸困难指数(transition dyspnoea index,TDI)及6min步行试验(6 minute walking test,6MWT).结果治疗前,两组患者肺功能、血气指标、TDI、6MWT及生活质量均无显著差异(均P>0.05).治疗后,试验组患者总有效率显著高于对照组(P<0.05);两组患者肺功能、血气指标、TDI及6MWT水平较治疗前均显著改善(均P<0.05),且试验组患者肺功能、血气指标、TDI、6MWT及生活质量均显著优于对照组(均P<0.05).结论针对缓解期COPD,布地奈德莫特罗干粉吸入较氨茶碱口服治疗,其临床效果更确切,对于血气指标及肺功能优化更明显,值得在临床推广.
Objective To compare the efficacy of budesonide/formoterol inhalation and aminophylline in the treatment of chronic obstructive pulmonary disease (COPD) in remission stage. Methods 146 patients with COPD in remission stage were randomly divided into 2 equal groups: control group treated with aminophylline tablet orally 0. 1~0.2 g t.i.d. for I month and experimental group treated with budesonide/formoterol dry powder inhalation therapy once per day for 1 month. The total effective rale, lung function, blood gas indexes, quality of life, transition dyspnoea index (TDI), and 6-minute walking test (6MWT) were compared between the two groups. Results Before treatment, there were no significant differences in lung function, blood gas indexes, TDI, 6MWT, and quality of life between these two groups (all P >0.05). After treatment, the total effective rale of the experimental group was 89.81%, significantly higher than that of the control group (73.15%, P < 0.05), The FEV 1%)、forced vital capacity ( FVC), inspiratory capacity (IC), pressure of arterial oxygen (PaO2), pressure of arterial carbon dioxide (PaCO2), PaCO,), and 6MWT levels were all significantly belter than those of the control group (all P < 0.05). Conclusion Budesonide fompdrol dry powder inhalation is more effective than aminophylline treated orally in treating COPD in remission stage, especially in blood gas indexes and lung function optimization.
作者
林敬明
陈文丽
郑辉才
王碧玉
吴淑华
张璐璐
LIN Jing-ming;CHEN Wen-li;ZHENG Hui-cai;WANG Bi-yu;WU Shu-hua;ZHANG Lu-lu(Department of RespiratoryMedicine, Third People's Hospital of Hainan, Haikou 572000,China)
出处
《中国急救复苏与灾害医学杂志》
2019年第7期635-638,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
关键词
布地奈德福莫特罗
氨茶碱
慢性阻塞性肺疾病
血气指标
肺功能
Budesonide nioterro
Aminophylline
Chronic obstructive pulmonary disease
Blood gas index
Lung function
