摘要
目的探讨跌打七厘片联合吲哚美辛巴布膏治疗急性软组织损伤的临床疗效。方法选取2016年3月-2018年3月在天津市津南区咸水沽医院治疗的156例急性软组织损伤患者作为临床研究对象进行研究,所有患者随机分为对照组和治疗组,每组各78例。对照组患者给予吲哚美辛巴布膏贴于患处,2次/d;治疗组在对照组基础上口服跌打七厘片,2片/次,3次/d。两组患者均连续治疗1周。观察两组的临床疗效,比较两组的疼痛消失时间、消肿时间、疼痛评分、症状积分和血清TNF-α、IL-6水平。结果治疗后,对照组和治疗组的总有效率分别为87.18%、97.44%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组患者疼痛消失时间、消肿时间均显著短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者视觉模拟评分法(VAS)评分、症状积分均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组患者VAS评分和症状积分均明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗组TNF-α、IL-6水平均显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论跌打七厘片联合吲哚美辛巴布膏治疗急性软组织损伤具有较好的临床疗效,能缓解患者临床症状,改善患者血清相关细胞因子水平,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Dieda Qili Tablets combined with Indometacin Cataplasm in treatment of acute soft tissue injury. Methods Patients(156 cases) with acute soft tissue injury in Jinnan District Xianshuigu Hospital of Tianjin from March 2016 to March 2018 were randomly divided into control and treatment groups, and each group had 78 cases. Patients in the control group were external administered with Indometacin Cataplasm, twice daily. Patients in the treatment group were po administered with Dieda Qili Tablets on the basis of the control group, 2 tablets/time, three times daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacies were evaluated, and pain disappearance time, swelling elimination time, pain scores, symptom scores, and the serum levels of TNF-α and IL-6 in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 87.18% and 97.44%, respectively, and there was difference between two groups(P < 0.05). After treatment, the pain disappearance time and swelling elimination time in the treatment group were significantly shorter than those in the control group, and there was difference between two groups(P < 0.05). After treatment, pain scores and symptom scores in two groups were significantly decreased, and the difference was statistically significant in the same group(P <0.05). And pain scores and symptom scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the serum levels of TNF-α and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05).Conclusion Dieda Qili Tablets combined with Indometacin Cataplasm has clinical curative effect in
作者
李雪寒
葛站勇
张秀丽
LI Xue-han;GE Zhan-yong;ZHANG Xiu-li(Department of orthopedics, Jinnan District Xianshuigu Hospital of Tianjin, Tianjin 300350,China;Department of Joint Surgery, Tianjin Hospital, Tianjin 300211, China)
出处
《现代药物与临床》
CAS
2019年第7期2123-2126,共4页
Drugs & Clinic
