摘要
目的:探讨激光光凝联合羟苯磺酸钙及血栓通对糖尿病视网膜病变微循环及炎性因子的影响。方法:选取DR患者86例,按照数字列表法随机分为对照组和联合组,每组43例。对照组给予激光光凝治疗,联合组在激光光凝治疗基础上加用羟苯磺酸钙及血栓通治疗。观察两组治疗前后血管瘤、黄斑、出血斑、视力、视野灰度值、视网膜中央动脉及睫状后短动脉的峰值血流速度(PSV)、舒张末期血流速度(EDV)、阻力指数(RI)及空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、血钙、血浆黏度、红细胞聚集指数、红细胞变形指数、血小板聚集率、低氧诱导因子-1(HIF-1)、血管内皮生长因子(VEGF)、白细胞介素1β(IL-1β)、基质金属蛋白酶9(MMP-9)等指标。比较两组临床疗效。结果:①联合组治疗总有效率(95.35%)明显高于对照组(72.09%)(P<0. 05)。②两组治疗后FBG、P2hBG、HbA1c较治疗前均有下降(P<0.05),但两组差异无统计学意义(P>0.05)。③与治疗前比较,两组治疗后血管瘤、黄斑、出血斑、视力、视野灰度值、血浆黏度、红细胞聚集指数、红细胞变形指数、血小板聚集率、视网膜中央动脉及睫状后短动脉PSV、EDV、RI及HIF-1α、VEGF、IL-1β、MMP-9水平均有改善(P<0.05),但联合组改善情况显著优于对照组(P<0.05)。结论:与激光单用相比,激光联合羟苯磺酸钙及血栓通治疗DR的疗效显著,可显著改善患者的微循环和炎性反应状态,临床应用价值较高。
Objective: To study the effects of laser photocoagulation combined with calcium dobesilate and Xueshuantong on microcirculation and inflammatory factors in patients with diabetic retinopathy(DR). Methods: 86 patients with DR in our hospital were selected as research objects.According to the number table, the patients were divided randomly into control group and combination group, 43 cases in each group. On the basis of conventional treatment for diabetes mellitus,the control group was treated with laser photocoagulation,the combination group was treated with laser photocoagulation combined with calcium dobesilate and Xueshuantong. Hemangioma, macular, blood spots, visual acuity,visual field gray value, peak flow velocity(PSV), end-diastolic velocity(EDV), resistance index(RI) of central retinal artery and posterior ciliary artery, and fasting plasma glucose(FPG), 2 h postprandial blood glucose(2 h PG), glycosylated hemoglobin(HbA1 c), blood calcium, blood plasma viscosity, erythrocyte aggregation index, erythrocyte deformation index, platelet aggregation rate, hypoxic induction factor-1(HIF-1) and vascular endothelial growth factor(VEGF), interleukin 1β(IL-1β), matrix metalloproteinase 9(MMP-9) before and after treatment were supervised in the two groups. Clinical efficacy was compared between the two groups. Results:①The total effective rate 95.35%) of the combination group was significantly higher than that of the control group72.09%)(P<0.05).②Compared with those before teeatment, FBG, P2 hBG and HbA1 c decreased after treatment in the two groups,(P<0.05), but the difference between the two groups was not statistically significant(P>0.05).③Compared with those before teeatment, Hemangioma, macular, blood spots, visual acuity,visual field gray value, PSV, EDV, RI of central retinal artery and posterior ciliary artery, blood plasma viscosity, erythrocyte aggregation index, erythrocyte deformation index, platelet aggregation rate, HIF-1, VEGF, IL-1β, MMP-9 improved after treatment in the two groups(P<0.05)
作者
李莉
Li Li(Ophthalmology Department,Fourth People’s Hospital of Langfang City,Langfang,Hebei 065700,China)
出处
《应用激光》
CSCD
北大核心
2019年第3期530-534,共5页
Applied Laser
关键词
糖尿病视网膜病变
激光光凝
羟苯磺酸钙
血栓通
微循环
炎性因子
diabetic retinopathy
laser photocoagulation
calcium dobesilate
Xueshuantong
microcirculation
inflammatory factors
