摘要
目的探讨双相情感障碍躁狂发作患者攻击行为与执行功能之间的相关性。方法采用修订版外显攻击行为量表(MOAS)对2018年6月—2019年2月在山东省精神卫生中心门诊就诊或者住院治疗的164例双相情感障碍躁狂发作患者攻击行为进行评定,MOAS评分≥5分为攻击组,MOAS<5分为非攻击组。用威斯康星卡片分类测验(WCST)评估受试者的执行功能,用贝克-拉范森躁狂量表(BRMS)评估受试者的临床症状。结果双相情感障碍躁狂攻击组患者BRMS总分[(25.78±4.32)分]高于非攻击组[(24.69±4.29)分](P<0.05),攻击组WCST正确数[(42.52±7.23)分]、分类数[(7.61±3.48)分]低于非攻击组[(44.29±9.14)、(8.06±2.12)分];错误数[(43.03±8.43)分]、持续错误数[(29.08±5.55)分]、非持续错误数[(26.84±5.78)分]均高于非攻击组[(41.32±8.18)、(28.58±7.22)、(25.03±5.80)分],差异有统计学意义(P<0.05),双相情感障碍躁狂患者MOAS评分与WCST错误数、持续性错误数、非持续性错误数呈正相关(P<0.05),与分类数呈负相关(P<0.05)。结论双相情感障碍躁狂患者攻击行为与执行功能存在相关性,执行功能受损可能与双相情感障碍躁狂攻击行为的发生机制有关。
Objectives To investigate the correlation between aggressive behavior and executive function in patients with bipolar mania. Methods From June 2016 to February 2019, a total of 164 patients with bipolar mania from Shandong Mental Health Center were evaluated for the aggressive behavior by the Modified Overt Aggression Scale (MOAS). The patients with MOAS score equal and over 5 was divided into aggression group and less than 5 into non-aggression group. The executive function of the subjects was evaluated by Wisconsin Card Sorting Test (WCST), and the clinical symptoms of the subjects were evaluated by BechRafaelsen Mania Rating Scale (BRMS). Results The total score of BRMS (25.78±4.32) in the aggression group was higher than that in the non-aggression group (24.69±4.29)(P<0.05), and the correct number (42.52±7.23) and the classification of WCST (7.61±3.48) in the aggression group were lower than those in the non-aggression group [(44.29±9.14),(8.06±2.12)]. The number of errors (43.03±8.43), perseverative errors (29.08±5.55) and non-perseverative errors (26.84±5.78) in the aggression group were higher than those in the non-aggression group [(41.32±8.18),(28.58±7.22),(25.03±5.80)](P < 0.05). The MOAS score of bipolar manic patients was positively correlated with the number of WCST errors, perseverative errors and non-perseverative errors (P< 0.05), however negatively correlated with the number of classifications (P< 0.05). Conclusions There is a correlation between aggressive behavior and executive function in patients with bipolar mania, and the impairment of executive function may be related to the mechanism of the aggressive behaviors with bipolar mania.
作者
马海波
Ma Haibo(Department of Psychiatry, Shandong Mental Health Center, Jinan 250014, China)
出处
《神经疾病与精神卫生》
2019年第5期443-446,共4页
Journal of Neuroscience and Mental Health
基金
山东省医药卫生科技发展计划项目(2018WS300).
关键词
双相情感障碍
躁狂
攻击行为
执行功能
Bipolar disorder
Mania
Aggressive behavior
Executive function
