摘要
目的探讨疏肝健脾固髓方联合依达拉奉对多发性硬化患者的近、远期临床疗效。方法选取医院2012年1月至2015年1月收治的多发性硬化患者84例,按治疗方法的不同分为对照组(40例)和观察组(44例)。两组患者均予以依达拉奉注射液治疗,观察组加用疏肝健脾固髓方。两组患者均治疗2周,治疗结束后随访3年。结果观察组总有效率为90.91%,显著高于对照组的75.00%(χ^2=5.096,P=0.024<0.05);与治疗前比较,两组患者治疗后临床症状评分、神经功能体征评分、神经功能障碍评分均显著降低,复发间期均显著延长,复发次数均显著减少,生活质量评分均显著升高(P<0.05),且观察组上述指标改善情况均显著优于对照组(P<0.05);观察组患者不良反应发生率为4.55%,显著低于对照组的20.00%(χ^2=4.772,P=0.029<0.05)。结论疏肝健脾固髓方联合依达拉奉可改善多发性硬化患者的临床症状、神经功能和生活质量,提高总有效率和减少复发次数,且不增加不良反应。
Objective To investigate the effect of Shugan Jianpi Gusui Recipe combined with edaravone on the short-term and long -term clinical efficacy of patients with multiple sclerosis.Methods Totally 84 patients with multiple sclerosis admitted to our hospital from January 2012 to January 2015 were selected and divided into the control group (n=40) and the observation group (n= 44) according to different treatment methods.The patients in the two groups were treated with Edaravone Injection,on this basis,the patients in the observation group were treated with Shugan Jianpi Gusui Recipe.The patients in the two groups were treated for 2 weeks and followed up for 3 years.Results The total effective rate of the observation group was 90.91%,which was significantly higher than 75.00% of the control group(χ^2=5.096,P=0.024<0.05).Compared with those before treatment,the scores of clinical symptom,neurological signs and neurological dysfunction were significantly decreased,the recurrence interval was significantly prolonged,the recurrence times were significantly reduced,the quality of life score was significantly increased in the two groups after treatment(P<0.05),and the improvement of the above indexes in the observation group was significantly better than that in the control group(P<0.05).The incidence of adverse reactions in the observation group was 4.55%,which was significantly lower than 20.00% in the control group (χ^2= 4.772,P=0.029<0.05).Conclusion Shugan Jianpi Gusui Recipe combined with edaravone can improve the clinical symptoms,neurological function and quality of life of patients with multiple sclerosis,it also can improve the total effective rate and reduce the recurrence times without increasing adverse reactions.
作者
张会朵
齐凡星
康丽娟
李恳
ZHANG Huiduo;QI Fanxing;KANG Lijuan;LI Ken(Department of Neurology,Baoding First Central Hospital,Baoding,Hebei,China,071000)
出处
《中国药业》
CAS
2019年第16期59-61,共3页
China Pharmaceuticals
基金
河北省保定市科技计划项目[17ZF074]
关键词
疏肝健脾固髓方
依达拉奉
多发性硬化
临床疗效
Shugan Jianpi Gusui Recipe
edaravone
multiple sclerosis
clinical efficacy
