摘要
目的:评价活血化瘀中药注射液治疗肺血栓栓塞症的有效性及安全性。方法:系统检索CNKI、WANFANG DATA、VIP、SinoMed、EMbase、PubMed、The Cochrane Library,按照预先设定纳入与排除标准筛选随机对照临床试验,应用风险评估工具进行研究质量评价,提取数据并运用Revman 5.3软件进行Meta分析。共检索到413篇文献,纳入12个研究,总样本数为1005例,试验组503例和对照组502例。结果:在西医常规治疗的基础上联合活血化瘀中药注射液治疗肺血栓栓塞症,与单用西医治疗相比,能提高总有效率[RR=1.15,95%CI (1.07,1.24)];降低D-二聚体[SMD=-1.16,95%CI (-1.79,-0.53)];增加氧分压[MD=15.45,95%CI (8.62,22.29)];降低BNP[MD=-130.48,95%CI (-140.58,-120.38)];降低肺动脉压[MD=-6.55,95%CI (-8.85,-4.24)]。但两组二氧化碳分压(PaO2)、肌钙蛋白(cTnI)差异无统计学意义(P>0.05)。不良反应较轻微。结论:活血化瘀中药注射液联合西医治疗肺血栓栓塞症,疗效优于单用西医治疗。但由于纳入研究质量偏低,研究结论仍有待更多高质量随机对照试验加以验证。
Objective: To evaluate the efficacy and safety of herb injections promoting blood circulation in the treatment of pulmonary thromboembolism. Method: The databases of Embase, PubMed, Cochrane Library, SinoMed, CNKI, VIP and WANFANG DATA were searched by computer, and randomized controlled trials were collected according to the preset inclusion criteria and exclusion criteria. Then risk assessment tools were used for quality evaluation of the studies, and data extraction and analysis were conducted by RevMan 5.3 software for Meta-analysis. A total of 413 articles were retrieved. And there were 12 RCTs enclosed involving 1005 patients, including 503 cases in experimental group and 502 cases in control group. Result: Compared with conventional medicine, herb injections promoting blood circulationshowed more efficiency[RR=1.15, 95% CI(1.07, 1.24)], reduced D-dimer [SMD=-1.16, 95% CI(-1.79,-0.53)];increased PaO2[MD=15.45, 95% CI(8.62, 22.29)];reduced BNP [MD=-130.48, 95% CI(-140.58,-120.38)];ruduced pulmonary artery pressure [MD=-6.55, 95% CI(-8.85,-4.24)]. But there was no significant difference between the two groups in PaCO2 and cTnI. The main adverse reactions reported were subcutaneous hemorrhage and rash. Conclusion: Integrated herb injections promoting blood circulation and western medicine showed more efficacy than conventional medicine in treatment of pulmonary thromboembolism. However, because of low-quality in the included studies, more high-quality randomized controlled trials would be needed in the future.
作者
王憭瑶
李宣霖
张康
刘冉
王海峰
余学庆
李素云
WANG Liaoyao;LI Xuanlin;ZHANG Kang;LIU Ran;WANG Haifeng;YU Xueqing;LI Suyun(Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province,Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2019年第7期1663-1668,共6页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81473799,81774222)
国家中医药管理局国家中医临床研究基地业务建设科研专项项目(JDZX2015152)
河南省特色学科建设项目(STS-ZYX2017002)
关键词
活血化瘀中药注射液
肺血栓栓塞症
META分析
herbinjections promoting blood circulation
pulmonary thromboembolism
Meta analysis
