摘要
脓毒症继发心功能障碍发病率、病死率均较高,是严重威胁人类健康的疾病.但该病发病机制目前尚不明确,许多研究表明脓毒症可通过多种直接或间接因素对心脏功能造成不良影响,如自主神经调节功能损伤、促炎介质和活化的免疫细胞引起的心肌病等,目前尚无统一的诊断标准和治疗方案.而稳定可靠的动物模型是明确脓毒症继发心功能障碍发病机制、病理生理过程和治疗方式的重要手段.目前有关脓毒症致心功能障碍动物模型较多,但仍无稳定可靠、特异性高的动物模型.因此,构造稳定可靠的模型是研究此类疾病的重要前提.统一的心功能障碍标准有利于全世界相关研究的整合和进一步发展.本文通过对脓毒症继发心功能障碍发病机制,以及常见脓毒症继发心功能障碍动物模型制备方法、生物标志物、基础研究等方面进行综述,以期为研究者选择合适的动物模型提供部分参考.
Sepsis-induced myocardial dysfunction (SIMD) has a high morbidity and mortality, and seriously threatens human health. However, the pathogenesis of the SIMD is still unclear. The previous studies have showed that the SIMD can adversely affect cardiac function through a variety of direct or indirect mechanism, such as autonomic nervous system function damage, pro-inflammatory mediators and activated immune cells induced cardiomyopathy. There is no uniform diagnostic criteria and treatment options. A stable and reliable animal model plays important role in the study that determine the pathogenesis, pathophysiological processes and treatment of SIMD. At present, there are many animal models of cardiac dysfunction caused by sepsis, unfortunately there is no stable, reliable and specific animal model at present. Therefore, it is important to construct a stable and reliable model for studying SIMD. The unified standard of cardiac dysfunction is conducive to the integration and further research. This review focused on pathogenesis of SIMD, routine ways of animal model of SIMD, observation index and basic research to provide references for the researcher to choose the proper animal model.
作者
张懿
布祖克拉·阿布都艾尼
彭鹏
Zhang Yi;Buzukela Abuduaini;Peng Peng(Department of Emergency, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2019年第6期785-788,共4页
Chinese Critical Care Medicine
基金
国家自然科学基金(81860335).
