摘要
目的观察溃疡性结肠炎(ulcerative colitis,UC)患者焦虑、抑郁心理的发病情况及血清5-HT、IL-6、IL-8、IL-2的表达特点,分析其与疾病的活动关系,并探讨焦虑、抑郁心理影响UC发病的可能机制。方法病例组:选择2013年1月至2018年3月在连云港市第二人民医院和蚌埠医学院第一附属医院消化内科就诊的门诊及住院UC患者121例,按病情分期及严重程度分级标准分为:A组:缓解期患者;B组:活动期患者;其中B组活动期患者又分为:C组:轻度活动期患者;D组:中-重度活动期患者。对照组:健康体检者,共30名。采用汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)测定UC患者焦虑、抑郁心理的发病情况;ELISA法检测患者血液中5-HT、IL-6、IL-8、IL-2的含量。结果病例组HAMA、HAMD评分及5-HT、IL-6、IL-8含量均显著高于对照组(P<0.05),IL-2含量显著低于对照组(P<0.01);B组患者HAMA、HAMD评分及5-HT、IL-6、IL-8含量均显著高于A组患者(P<0.05),IL-2含量显著低于A组患者(P<0.05);D组患者HAMA、HAMD评分及5-HT、IL-6、IL-8含量均显著高于C组患者(P<0.05),IL-2含量显著低于C组患者(P<0.05)。病例组HAMA评分、HAMD评分均与5-HT、IL-6、IL-8的含量呈显著正相关,与IL-2呈显著负相关。结论焦虑、抑郁心理可能通过改变5-HT等神经递质的分泌,经神经-内分泌-免疫网络改变脑-肠轴功能,影响免疫系统IL-6、IL-8、IL-2等细胞因子的分泌,参与UC的发病。
Objective To observe the incidence of anxiety and depression and the expressions of serum 5-HT,IL-6,IL-8 and IL-2 in ulcerative colitis (UC) patients,and analyze its relationship with disease activity.To explore the possible mechanism of anxiety and depression in the pathogenesis of UC. Methods Case group:121 UC outpatients and inpatients in the Department of Gastroenterology of the Second People’s Hospital of Lianyungang City and the First Affiliated Hospital of Bengbu Medical College from Jan.2013 to Mar.2018 were chosen.According to the illness severity stages and classification standard,they were divided into group A (remission patients) and group B (active patients).Group B was divided into group C (mildly active patients) and group D (moderately to severely active patients).Control group:30 cases of health examination were chosen.The prevalence of anxiety and depression in UC patients was measured by Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD).The levels of 5-HT,IL-6,IL-8 and IL-2 in the blood of these patients were detected by ELISA. Results The scores of HAMA and HAMD and the levels of 5-HT,IL-6 and IL-8 in the case group were significantly higher than those in control group ( P <0.05 ),but the level of IL-2 was significantly lower than that in control group ( P <0.01).The scores of HAMA and HAMD and the levels of 5-HT,IL-6 and IL-8 in group B were significantly higher than those in group A ( P < 0.05 ),but the level of IL-2 was significantly lower than that in group A ( P <0.05).The scores of HAMA and HAMD and the levels of 5-HT,IL-6 and IL-8 in group D were significantly higher than those in group C ( P <0.05 ),but the level of IL-2 was significantly lower than that in group C ( P <0.05).The scores of HAMA and HAMD in the case group were significantly positive correlated with the levels of 5-HT,IL-6 and IL-8,but it was significantly negative corr- elated with IL-2. Conclusion Anxiety and depression may involve in the pathogenesis of UC by affecting the secretion of cytokines of
作者
赵昌东
赵红艳
柯希权
张小节
张辉
王淑芳
李雪
ZHAO Changdong;ZHAO Hongyan;KE Xiquan;ZHANG Xiaojie;ZHANG Hui;WANG Shufang;LI Xue(Department of Gastroenterology,the Second People’s Hospital of Lianyungang City,Affiliated Hospital of Bengbu Medical College,Lianyungang 222023;Department of Ultrasound,Lianyungang Hospital of Traditional Chinese Medicine;Department of Gastroenterology,the First Affiliated Hospital of Bengbu Medical College,China)
出处
《胃肠病学和肝病学杂志》
CAS
2019年第7期791-795,共5页
Chinese Journal of Gastroenterology and Hepatology
基金
蚌埠医学院科技发展基金项目(BYKY14141)
