摘要
目的比较分析两种新型抗癫痫药左乙拉西坦与拉莫三嗪治疗新诊断儿童癫痫疗效及对认知功能的影响,为临床儿童抗癫痫治疗提供一定的理论指导。方法80例新诊断癫痫患儿,随机分为左乙拉西坦组和拉莫三嗪组,各40例。左乙拉西坦组给予左乙拉西坦治疗,拉莫三嗪组给予拉莫三嗪治疗。比较两组临床疗效、不良反应发生情况及精神状态检测量表(MMSE)评分。结果左乙拉西坦组的总有效率为97.5%,拉莫三嗪组的总有效率为92.5%,两组比较差异无统计学意义(P>0.05)。两组药物治疗期间,左乙拉西坦组的不良反应发生率为7.5%,明显低于拉莫三嗪组的25.0%,差异有统计学意义(P<0.05)。治疗前及治疗后3、6个月,两组的MMSE评分比较差异均无统计学意义(P>0.05)。结论两种新型抗癫痫药左乙拉西坦和拉莫三嗪治疗新诊断儿童癫痫的临床疗效及对认知功能的影响没有明显的差异,但左乙拉西坦的不良反应明显少于拉莫三嗪,因此左乙拉西坦的总体效果要优于拉莫三嗪。
Objective To compare and analyze the efficacy of two new antiepileptic drugs of levetiracetam and lamotrigine in the treatment of newly diagnosed pediatric epilepsy and their effects on cognitive function, so as to provide some theoretical guidance for clinical antiepilepsy. Methods A total of 80 newly diagnosed epilepsy children were randomly divided into levetiracetam group and lamotrigine group, with 40 cases in each group. Group A was treated with levetiracetam, and group B was treated with lamotrigine. Comparison were made on clinical efficacy, occurrence of adverse reactions and mini-mental state examination(MMSE)scores in two groups. Results Levetiracetam group had total effective rate as 97.5%, and lamotrigine group had total effective rate as 92.5%, and the difference was not statistically significant(P>0.05). During drug therapy,levetiracetam group had lower incidence of adverse reactions as 7.5% than 25.0% in lamotrigine group, and the difference was statistically significant(P<0.05). Before treatment and after 3 and 6 months of treatment, both groups had no statistically significant difference in MMSE score(P>0.05). Conclusion There is no significant difference in the clinical efficacy and cognitive function between two new antiepileptic drugs of levetiracetam and lamotrigine in the treatment of newly diagnosed pediatric epilepsy, but the adverse reaction of levetiracetam is significantly less than that of lamotrigine, so the overall effect of levetiracetam is better than that of lamotrigine.
作者
袁圣勇
袁莉
潘北香
YUAN Sheng-youg;YUAN Li;PAN Bei-xiang(Maoming People's Hospital, Maoming 525000, China)
出处
《中国实用医药》
2019年第19期90-92,共3页
China Practical Medicine
关键词
左乙拉西坦
拉莫三嗪
儿童癫痫
认知功能
Levetiracetam
Lamotrigine
Pediatric epilepsy
Cognitive function
