摘要
目的比较住院危重和普通患者的革兰阴性菌耐药性。方法将我院收治的重症加强护理病房(ICU)患者256例设为重症组,普通病房患者324例设为普通组,使用纸片扩散法测定两组中分离出的革兰阴性菌的耐药性。结果两组主要菌株来源均为痰或肺灌洗液。重症组分离的大肠埃希菌少于普通组,鲍曼不动杆菌多于普通组(P<0.05)。重症组分离出的铜绿假单细胞菌对头孢曲松、亚胺培南、头孢吡肟的耐药性高于普通组(P<0.05);重症组分离出的大肠埃希菌对头孢曲松、头孢吡肟的耐药性高于普通组(P<0.05);重症组分离出的肺炎克雷伯菌对亚胺培南的耐药性高于普通组(P<0.05)。结论革兰阴性菌耐药性在住院危重和普通患者中存在较大差异,应根据药敏试验谨慎使用抗菌药物。
Objective To compare the drug resistance of Gram-negative bacteria in critically ill and ordinary patients.Methods A total of 256 ICU patients in our hospital were set as intensive group, and 324 patients in the general ward were set as general group. The resistance of Gram-negative bacteria isolated from the two groups was determined by Kirby-Bauer test. Results The main bacterial strain in both groups were isolated from sputum or lung lavage fluid. The Escherichia coli isolation from the intensive group was less than that isolated from the general group, and Acinetobacter baumannii was higher than that isolated from the general group (P<0.05). The resistances of Pseudomonas aeruginosa isolated from the intensive group to ceftriaxone, imipenem and cefepime were higher than those of the general group (P<0.05);the resistances of Escherichia coli isolated from the intensive group to ceftriaxone and cefepime were higher than those of the general group (P<0.05);the resistance of Klebsiella pneumoniae isolated from the intensive group to imipenem was higher than that of the general group (P<0.05). Conclusion The drug resistance of Gram-negative bacteria is significantly different between critically ill patients and ordinary patients, and antimicrobial agents should be used carefully according to drug sensitivity test.
作者
何霞辉
HE Xia-hui(120 First Aid Command Center of Huaibin County,Xinyang 464400,China)
出处
《临床医学研究与实践》
2019年第21期92-93,共2页
Clinical Research and Practice
关键词
革兰阴性菌
药敏性
抗菌药物
Gram-negative bacteria
drug susceptibility
antimicrobial agents
