摘要
目的研究痛消膏经皮单次给药对机体所产生的毒性反应,为其临床用药和推广提供实验依据。方法选取新西兰家兔为研究对象,采用最大给药量法及对照法观察痛消膏经皮单次给药后新西兰家兔出现的毒性反应情况。结果痛消膏经皮单次给药后对新西兰家兔未见明显毒性反应,亦未见死亡或濒死;对新西兰兔体质量及体质量增长未见明显影响;给药后第14天对全部实验新西兰家兔进行剖检,肉眼观察组织、器官病变,均未见明显异常改变。结论痛消膏经皮单次给药未见明显毒性反应,具有良好的安全性。
Objective:To study the toxic reaction of Tongxiao Ointment to organism by single transdermal administration,and to provide experimental basis for its clinical medication and promotion.Methods:New Zealand rabbits were selected as the study subjects.The maximum dose and contrast method were used to observe their toxicity after single transdermal administration.Results:There was no obvious toxicity in New Zealand rabbits after single transdermal administration,without death or sudden death.There was no significant effect on the growth and body weight of rabbits.On the 14 th day after the administration,all rabbits were examined with necropsy,and no obvious abnormal changes were observed in tissues and organ lesions.Conclusion:Tongxiao Ointment has no obvious toxicity and good safety by single transdermal administration.
作者
毛得宏
李国俊
郭亮
刘渝松
彭志财
金贵根
姜维成
郭剑华
Mao Dehong;Li Guojun;Guo Liang(Yongchuan District TCM Hospital of Chongqing,Chongqing 402160,China.)
出处
《中国中医急症》
2019年第7期1229-1231,共3页
Journal of Emergency in Traditional Chinese Medicine
基金
重庆市卫健委科研项目中医药科技计划项目(ZY201402154)
关键词
痛消膏
皮肤
单次给药
毒性实验
新西兰家兔
Tongxiao Ointment
Skin
Single dose
Toxicity test
New Zealand rabbit
