摘要
目的:探讨热休克蛋白HSP90α和HSP90β在骨肉瘤中的表达及意义。方法:采用免疫组化法检测90例骨肉瘤组织和21例癌旁组织中HSP90α和HSP90β的表达,并分析其与骨肉瘤临床病理特征的关系。结果:在骨肉瘤组织中,HSP90α和HSP90β的阳性表达率分别为57.78%和77.78%,均显著高于癌旁组织(P<0.05)。HSP90α高表达与骨肉瘤Enneking外科分期相关(P<0.05),而与患者性别、年龄、肿瘤位置无关(P>0.05)。HSP90β高表达与骨肉瘤Enneking外科分期相关(P<0.05),而与患者年龄、性别、肿瘤位置无关(P>0.05)。Spearman相关性分析显示,HSP90α和HSP90β在骨肉瘤中协同表达(r=0.247,P<0.05)。结论:HSP90α和HSP90β在骨肉瘤组织中共同表达上调,可能作为骨肿瘤潜在的诊断和治疗靶点。
Objective:To investigate the expression of HSP90αand HSP90βin osteosarcoma tissue and its clinical significance.Methods:The expression of HSP90αand HSP90βprotein in 90 osteosarcoma specimens and 21 tumor-adjacent normal tissue were detected by immunohistochemistry.The relationships between HSP90α,HSP90βand the clinicopathologic features of osteosarcoma were analyzed.Results:Among 90 cases,the positive expressions of HSP90αand HSP90βwere detected in 57.78%and 77.78%respectively.The expression of HSP90αand HSP90βin the cancer tissue were significantly higher than those in the tumor-adjacent normal tissue(P<0.05).The positive expression of HSP90αwas correlated with Enneking surgical staging(P<0.05),but not correlated with the gender,age and tumor location(P>0.05).The positive expression of HSP90βwas correlated with Enneking surgical staging(P<0.05),but not correlated with the gender,age and tumor location(P>0.05).Spearman rank correlation showed that HSP90αand HSP90βwere significantly correlated with each other(r=0.247,P<0.05).Conclusion:The expression of HSP90αand HSP90βare high in osteosarcoma,indicating that HSP90αand HSP90βmight be used as the potential diagnostic and therapeutic target for osteosarcoma.
作者
舒雄
孙晓淇
杰永生
郑蕊
刘辉琦
冉宇靓
Shu Xiong;Sun Xiaoqi;Jie Yongsheng;Zheng Rui;Liu Huiqi;Ran Yuliang(Beijing Jishuitan Hospital/the Institute of Traumatology and Orthopaedics,Beijing 100035,China;Qinghai University,Qinghai Xining 810016,China;National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
出处
《现代肿瘤医学》
CAS
2019年第16期2823-2826,共4页
Journal of Modern Oncology
基金
中国医学科学院医学与健康科技创新工程(编号:2016-I2M-3-013,2017-I2M-3-005)
