摘要
目的探讨克罗恩病(CD)患者血清前白蛋白(PA)水平。方法选取武汉大学人民医院消化内科自2017年1月至2018年4月收治的47例CD患者为研究对象,设为CD组,并根据患者病情程度分为轻度组(n=18)、中度组(n=23)及重度组(n=6);另选取32例健康志愿者为健康组。分别于入院后次日清晨采空腹血,检测血清PA、白蛋白(ALB)、红细胞沉降率(ESR)及C反应蛋白(CRP)水平。比较轻度组、中度组及重度组PA水平,采用Pearson相关分析对CD患者PA与ESR、ALB、CRP的相关性进行分析。结果与健康组比较,CD组患者ESR及CRP水平明显增高,血清PA及ALB水平降低,差异有统计学意义(P<0.05)。轻度组患者PA为(204.00±69.14)mg/L、中度组患者PA为(178.76±54.45)mg/L、重度组患者PA为(153.96±41.15)mg/L。中度组及重度组患者PA水平显著低于轻度组,且重度组患者PA水低于中度组,组间比较,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,CD组中血清PA水平与ESR、CRP水平呈负相关(r=-0.57,r=-0.30,P<0.05),与血清ALB水平呈正相关(r=0.65,P<0.05)。结论血清PA水平可反映CD的疾病严重程度,且血清PA水平与ESR、CRP水平呈负相关,与血清ALB水平呈正相关。
Objective To investigate the serum prealbumin(PA)levels in patients with Crohn disease(CD). Methods A retrospective study was performed on 47 cases of CD patients who were admitted from January 2017 to April 2018.According to the illness degree,CD patients were divided into the mild group( n =18),moderate group( n =23)and severe group( n =6);another 32 cases of healthy volunteers were in the healthy group.Fasting blood was collected the next morning after admission,and serum PA,albumin(ALB),erythrocyte sedimentation rate(ESR)and c-reactive protein(CRP)levels were detected.PA levels in the mild,moderate and severe groups were compared,and the correlation between PA and ESR ALB and CRP in CD patients was analyzed by Pearson correlation analysis. Results Compared with the healthy group,ESR and CRP levels were significantly increased and serum PA and ALB levels were reduced in the CD group,with statistically significant differences( P <0.05).PA was(204.00±69.14)mg/L in the mild group,(178.76±54.45)mg/L in the moderate group and(153.96±41.15)mg/L in the severe group.The PA level of patients in the moderate group and the severe group was significantly lower than that in the mild group,and the PA water level of patients in the severe group was lower than that in the moderate group,with statistically significant differences between groups( P <0.05).Pearson correlation analysis results showed that serum PA level in group CD was negatively correlated with ESR and CRP level( r =-0.57,r =-0.30,P <0.05),and positively correlated with serum ALB level( r =0.65,P <0.05). Conclusion Serum PA level can reflect the severity of CD,and serum PA level is negatively correlated with ESR and CRP level,and positively correlated with serum ALB level.
作者
李玮
董卫国
LI Wei;DONG Wei-guo(Department of Gastroenterology,Renmin Hospital of Wuhan University,Wuhan 430060,China)
出处
《创伤与急危重病医学》
2019年第4期247-248,251,共3页
Trauma and Critical Care Medicine
