摘要
目的 探究冠心病合并2型糖尿病患者中医证型与血脂、血糖和心脏超声诊断结果等临床指标的关系,为中医辨证客观化提供临床证据。方法 共纳入300例冠心病合并2型糖尿病患者,观察并比较不同证型患者的血糖[空腹血糖(fasting plasma glucose, FPG)、餐后2 h血糖(2-hour postprandial blood glucose,2hPG)、糖基化血红蛋白A1c(glycosylated hemoglobin, HbA1c)]、血脂[三酰甘油(triglyceride, TG)、总胆固醇(total cholesterol, TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol, LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol, HDL-C)]、血同型半胱氨酸(homocysteine, HCY)、血C-反应蛋白(C-reactive protein, CRP)及心脏超声诊断结果[(左室内径(left ventricular diameter, LVD)、左室射血分数(left ventricular ejection fraction, LVEF)]。结果 不同证型的冠心病合并2型糖尿病患者FPG、HbA1c比较,差异有统计学意义(P<0.05);阳虚血瘀证患者TC、TG水平最高,而气虚痰阻证患者LDL-C最高;不同证型患者2hPG、HDL-C、CRP水平比较,差异无统计学意义(P>0.05)。气阴两虚证、气虚痰瘀证、阳虚血瘀证患者HCY、LVD水平依次递增,而LVEF依次递减。结论 不同证型冠心病合并2型糖尿病患者血糖、血脂和心脏超声结果等临床指标存在一定差异。
Objective To investigate the association of traditional Chinese medicine (TCM) syndrome type with blood lipids, blood glucose, and echocardiographic findings in patients with coronary heart disease and type2 diabetes, and to provide clinical evidence for objective TCM syndrome differentiation. Methods A total of 300 patients with coronary heart disease and type2 diabetes were enrolled. The patients with different TCM syndrome types were compared in terms of blood glucose [fasting plasma glucose (FPG),2-hour postprandial plasma glucose (2hPG), and glycosylated hemoglobin (HbA1c)], blood lipids [triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)], blood homocysteine (HCY), blood C-reactive protein (CRP), and echocardiographic findings [left ventricular diameter (LVD) and left ventricular ejection fraction (LVEF)]. Results There were significant differences in FPG and HbA1c between the patients with different TCM syndrome types (P<0.05). The patients with Yang deficiency and blood stasis syndrome had the highest levels of TC and TG, while those with Qi deficiency and phlegm stagnation syndrome had the highest level of LDL-C. There were no significant differences in2hPG, HDL-C, and CRP between the patients with different TCM syndrome types (P>0.05). There were gradual increases in HCY and LVD and a gradual reduction in LVEF in the patients with deficiency of both Qi and Yin, those with Qi deficiency and phlegm stasis, and those with Yang deficiency and blood stasis. Conclusion There are certain differences in blood glucose, blood lipids, and echocardiographic findings between patients with coronary heart disease and type2 diabetes who have different TCM syndrome types.
作者
邵正斌
黄平
夏铭蔚
梁国庆
戚先伟
左强
戴小华
SHAO Zheng-bin;HUANG Ping;XIA Ming-wei;LIANG Guo-qing;QI Xian-wei;ZUO Qiang;DAI Xiao-hua(The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230031,China;Institute of Cardiovascular Diseases, Anhui Academy of Chinese Medicine,Anhui Hefei 230031, China)
出处
《安徽中医药大学学报》
2019年第4期36-39,共4页
Journal of Anhui University of Chinese Medicine
基金
安徽省卫生计生委中医药科研课题项目(2016zy72)
安徽中医药大学探索性科研项目(2016ts047)
关键词
冠心病
2型糖尿病
中医证型
血糖
血脂
心脏超声
同型半胱氨酸
C-反应蛋白
Coronary heart disease
Type2 diabetes
Traditional Chinese medicine syndrome type
Blood glucose
Blood lipids
Echocardiography
Homocysteine
C-reactive protein
