摘要
骨肉瘤是一种原发于骨的常见恶性肿瘤,好发于儿童和青少年,长期以来5年生存率不到70%。目前,骨肉瘤的治疗已到达一个平台期,进一步的预后改善可能依赖于新的生物学疗法。miRNA在肿瘤中的作用日益被重视,其中miR-17-92基因簇作为致癌基因,在骨肉瘤中的作用也被广泛研究。本文综述mi R-17-92基因簇在骨肉瘤中的功能和机制,以期为骨肉瘤带来新的治疗方案。
Osteosarcoma is a common malignant tumor originating from bone and mainly occurs in children and adolescents. The 5-year survival rate is less than 70%. Currently, the treatment of osteosarcoma has reached a plateau, and further improvement in prognosis may depend on new biological therapies. The role of miRNAs in tumors has been increasingly recognized, and the miR-17-92 gene cluster has been used as an oncogene in osteosarcoma. This article reviews the function and mechanism of miR-17-92 gene cluster in osteosarcoma, to bring a new scheme for the diagnosis and treatment of osteosarcoma.
作者
王勃霏
姜晓玲
卢斌
蔡惠丽
陈海丹
WANG Bofei;JIANG Xiaoling;LU Bin;CAI Huili;CHEN Haidan(Institute of Spine Medicine and Trauma,People’s Hospital of Yichang City,Yichang 443000,China;Department of Etiology and Immunology,Medical College of China Three Gorges University Yichang 443002,China;Department of Hematology,The First Clinical Medical College Affiliated to China Three Gorges University,Yichang 443000,China)
出处
《肿瘤防治研究》
CAS
CSCD
2019年第7期635-638,共4页
Cancer Research on Prevention and Treatment
基金
湖北省卫生健康委员会青年人才项目(WJ2019Q01)
宜昌市医疗卫生科研项目(A19-301-12)
湖北省自然科学基金青年项目(2017CFB334)
湖北省教育厅科学研究项目(B2017018)