摘要
脂滴是细胞内中性脂的重要储存场所,参与细胞多种活动,是一个功能复杂的细胞器。病原微生物感染宿主后能够利用脂滴获取脂质而满足能量需求;脂滴也能为病毒复制提供组装平台,以利于病毒的复制和增殖。同时,脂滴释放的炎症介质以及其表面的病毒抑制蛋白、组蛋白在抵抗病原微生物感染中发挥重要作用。本文对脂滴的生物学特征及功能作简要概述,并对近年来相关研究进行综述。
Lipid droplets (LDs) are the intracellular sites for neutral lipid storage.They are recognized as functional organelles involved in various biological activities.Accumulating evidence shows that many pathogens use host LDs as lipids and energy resources during infection.LDs may also serve as assembly platforms for the replication and proliferation of pathogens.Besides,the inflammatory mediators released by LDs,as well as the viperin and the histones located on the surface of LDs,enable LDs to play a role in fighting against pathogens.Here,we give a brief overview on the lipid biology and functions of LDs,and review the recent findings.
作者
严梦楠
周建
李华茵
YAN Meng-nan;ZHOU Jian;LI Hua-yin(Department of Pulmonary Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China)
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2019年第4期535-539,共5页
Fudan University Journal of Medical Sciences
基金
国家自然科学基金面上项目(81570028)~~
关键词
脂滴
病原微生物
感染
lipid droplets
pathogen
infection
