摘要
目的评价经尿道等离子电切术联合吉西他滨膀胱灌注治疗非肌层浸润性膀胱癌的临床疗效。方法选取2014年1月至2016年1月黄石市中心医院应用经尿道等离子电切术联合术后吉西他滨或吡柔比星膀胱灌注化疗的非肌层浸润性膀胱癌患者84例,观察并比较两种药物灌注治疗后2年肿瘤复发率及不良反应发生率。结果两组患者的2年肿瘤复发率比较,差异无统计学意义,但吡柔比星组的不良反应发生率较吉西他滨组明显增高。结论吉西他滨膀胱灌注预防非肌层浸润性膀胱癌经尿道等离子电切术后膀胱肿瘤复发效果确切,且不良反应少,值得在临床上进一步推广应用。
Objective To evaluate the clinical effect of intravesical instillation of gemcitabine and transurethral resection of bladder tumor in the treatment of non-muscle-invasive bladder cancer. Methods From January 2014 to January 2016, 84 patients with non-muscle-invasive infiltration bladder cancer who underwent transurethral resection of prostatectomy combined with postoperative intravesical instillation of gemcitabine or pirarubicin in Huangshi Center Hospital were selected. The 2-year tumor recurrence rate and incidence of adverse reactions in both groups were observed and compared. Result There was no significant difference in 2-year tumor recurrence rates between the two groups, but the incidence of adverse reactions in the pirarubicin group was significantly higher than that in the gemcitabine group. Conclusions The bladder infusion of gemcitabine in bladder cancer patients has definite effect and low incidence of adverse reactions. It is worth further promoting in the clinical application.
作者
叶志华
董万超
熊智萍
桂定文
黄耿
付金伦
YE Zhihua;DONG Wanchao;XIONG Zhiping;GUI Dingwen;Huang Geng;FU Jinlun(Department of Urology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Edong Healthcare Group, Huangshi 435000, China)
出处
《现代泌尿生殖肿瘤杂志》
2019年第3期147-149,共3页
Journal of Contemporary Urologic and Reproductive Oncology
关键词
膀胱肿瘤
吉西他滨
吡柔比星
膀胱灌注
Urinary bladder neoplasma
Gemcitabine
Pirarubicin
Bladder perfusion
