摘要
Near-infrared(NIR)fluorescent dyes based on small organic molecules are characterized with low cytotoxicity,good biocompatibility and minimum interference from auto-fluorescence background,which are widely used in tumor diagnosis.Intensive research on molecular properties and photothermal properties of fluorescent dyes have been explored for non-invasive photothermal treatment of cancer.In this review,we focus on the development of imaging-induced photothermal therapy of small molecules and classification according to the structures of organic molecules including cyanines,phthalocyanines,rhodamine analogues and BODIPYs.
Near-infrared(NIR)fluorescent dyes based on small organic molecules are characterized with low cytotoxicity,good biocompatibility and minimum interference from auto-fluorescence background,which are widely used in tumor diagnosis.Intensive research on molecular properties and photothermal properties of fluorescent dyes have been explored for non-invasive photothermal treatment of cancer.In this review,we focus on the development of imaging-induced photothermal therapy of small molecules and classification according to the structures of organic molecules including cyanines,phthalocyanines,rhodamine analogues and BODIPYs.
基金
the Natural Science Foundation Committee of China(NSFC, No. 81671803)
the National Key Research and Development Program(No. 2017YFC0107700)
the Outstanding Youth Foundation of Jiangsu Province (Nos. GX20171114003, BK20170030)
Fok Ying Tung Education Foundation(No. 161033)
"Double First-Class" University project(Nos. CPU2018GY06 and CPU2018GY24)
the Priority Academic Program Development of Jiangsu Higher Education Institutions, for their financial support
the National Natural Science Foundation of China(Nos. 21676113,21402057, 21772054, 21472059)
Distinguished Young Scholar of Hubei Province(No. 2018CFA079)for the financial support
supported by the 111 Project (No. B17019)
