摘要
目的:分析多发性骨髓瘤(MM)合并肾损害患者的临床及病理特征,以提高诊断和治疗水平。方法:回顾性分析MM合并肾损害的22例患者的临床及病理资料。结果与结论:MM合并肾损害的临床症候群以肾功能不全最为常见(72.7%),常伴有高尿酸血症,同时尿蛋白检出率高,但大量蛋白尿发生率较低。MM合并肾损害患者肾脏病理表现多样,不同病理类型具有各自的临床特点,与淀粉样变性患者相比,非淀粉样变性患者贫血相对较重,肌酐升高程度更明显,尿本周蛋白阳性率高(P<0.05)。血免疫电泳轻链阳性率86.4%(19/22),尿中轻链阳性率为75.0%(9/12),均以λ轻链为主。
Aim :To analyze the clinical and pathological features of patients with multiple myeloma(MM) complicated with renal impairment,so as to improve diagnosis and treatment levels. Methods :The clinical and pathological data of 22 patients who were diagnosed MM with renal impairment were retrospectively analyzed. Results and Conclusion :The most common clinical syndrome of MM with renal impairment was renal insufficiency(72.7%), often accompanied with hyperuricemia, and the detection rate of urinary protein was high, but the incidence of proteinuria was low. Renal pathological manifestations of MM patients with renal impairment were diverse. Different pathological types had their own clinical features. Compared with patients with amyloidosis, patients with non-amyloidosis had relatively severe anemia, and creatinine increased more significantly,and the positive rate of Bence-Jones protein in urine was high( P <0.05). The blood immunoelectrophoresis light chain positive rate was 86.4%(19/22), and the urinary light chain positive rate was 75.0%(9/12), among which were mainly λ light chain.
作者
王芳
吴歌
张珊珊
姜中兴
田文亮
谢新生
曹伟杰
WANG Fang;WU Ge;ZHANG Shanshan;JIANG Zhongxing;TIAN Wenliang;XIE Xinsheng;CAO Weijie(Department of Hematology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052;Department of Nephrology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052)
出处
《郑州大学学报（医学版）》
CAS
北大核心
2019年第4期631-634,共4页
Journal of Zhengzhou University(Medical Sciences)
基金
河南省卫计委科技攻关项目(201403034)
河南省医学科技攻关计划省部共建项目(SBGJ2018035)
关键词
多发性骨髓瘤
肾损害
轻链蛋白
multiple myeloma
renal impairment
light chain protein
