摘要
细菌性慢性呼吸道感染是严重威胁人类健康和制约社会经济发展的常见疾病。呼吸道环境和结构的复杂性导致慢性感染病灶常常定植着多种病原菌,如铜绿假单胞菌Pseudomonas aeruginosa、金黄色葡萄球菌Staphylococcus aureus、大肠埃希氏菌Escherichia coli、肺炎克雷伯氏菌Klebsiella pneumoniae、鲍曼不动杆菌Acinetobacter baumannii和白色念珠菌Candida albicans等。这些病原菌在慢性呼吸道感染的发展过程中进化出了合作、竞争、共生等复杂的种间关系,通过形成相对稳定的群落系统使多种病原菌成为一个整体来应对呼吸道各种苛刻的生存条件,从而导致呼吸道感染针对性治疗的失败或病情反复。目前国际上关于病原菌种间互作关系的研究正处于起步阶段,临床证据表明铜绿假单胞菌的定植与慢性呼吸道感染的发生、发展息息相关,并且该菌可以利用群体感应系统来主导与其他病原菌的互作与共存。因此,本文围绕群体感应系统综述了铜绿假单胞菌与其他常见呼吸道感染病原菌的种间关系和互作机理,可加深人们对病原菌种间互作与慢性呼吸道感染相关疾病关联性的认识,并为进一步临床治疗方案的改进、疾病控制和新型抗感染药物的研发提供新视角、新方向。
Bacterial chronic respiratory infections are common diseases that threaten the health of people worldwide and restrict social and economic development.The complexity of respiratory tract environment and structure frequently lead to the colonization of a variety of bacterial pathogens,such as Pseudomonas aeruginosa,Staphylococcus aureus,Escherichia coli,Klebsiella pneumoniae,Acinetobacter baumannii,and Candida albicans.These pathogens evolve complex interspecific relationships including cooperation,competition,and symbiosis as chronic lung infection progress.By forming a relatively stable community system,multiple pathogens can integrate to cope with the harsh living conditions of the respiratory tract,resulting in the failure of targeted treatment or recurrence of respiratory infections.At present,revealing the underlying interaction mechanism among coexisting bacterial pathogens is an emerging subject,and clinical evidences have indicated that the colonization of P.aeruginosa is closely related to the development of chronic respiratory infections,and this microorganism can use elaborate quorum-sensing system to dominate the growth and coexistence of other pathogens.Therefore,this paper reviews the interspecific relationship and interaction mechanism between P.aeruginosa and other common respiratory infection pathogens mediated by the quorum-sensing system,and this can facilitate the understanding of the correlation between pathogen-pathogen interactions and chronic respiratory infections,and provide new perspectives and directions for further improvement of clinical treatment programs,disease control and the development of novel anti-infective drugs.
作者
袁阳
李静
王欣荣
赵克雷
YUAN Yang;LI Jing;WANG Xinrong;ZHAO Kelei(Antibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province,Sichuan Industrial Institute of Antibiotics,Chengdu University,Chengdu 610052,China)
出处
《四川动物》
北大核心
2019年第4期472-480,共9页
Sichuan Journal of Zoology
基金
国家自然科学基金青年基金项目(31700111)
四川省科学技术协会青年人才托举工程项目(2018RCTJ)
关键词
呼吸道感染
铜绿假单胞菌
群体感应系统
种间相互作用
respiratory tract infection
Pseudomonas aeruginosa
quorum-sensing system
interspecific interaction
