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右美托咪定联合达克罗宁胶浆用于肾功能不全患者经皮肾镜取石术临床评价 被引量:5

Clinical Evaluation on Dexmedetomidine Combined with Dyclonine Hydrochloride Mucilage Used in Percutaneous Nephrolithotomy for Patients with Renal Insufficiency
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摘要 目的探讨右美托咪定联合达克罗宁胶浆在肾功能不全患者经皮肾镜取石术(PCNL)中的应用效果。方法选取都江堰市人民医院2013年1月至2017年8月收治拟行PCNL的肾功能不全患者80例,按随机数字表法分为对照组(26例)、右美托咪定组(27例)及联合组(27例)。对照组术中给予0.9%氯化钠注射液,右美托咪定组给予盐酸右美托咪定注射液,联合组给予盐酸右美托咪定注射液和盐酸达克罗宁胶浆。结果与入室时(T1)比较,插管时(T2)、拔管时(T3)、拔管后5 min(T4)对照组患者的收缩压(SBP)、舒张压(DBP)升高,右美托咪定组患者T2~T4的SBP及DBP降低(P<0.05),联合组患者T2~T4的SBP与DBP比较无差异(P>0.05);右美托咪定组、联合组患者T2~T4的SBP与DBP均低于对照组,联合组高于右美托咪定组(P<0.05);与T1比较,对照组、右美托咪定组患者T2~T4的心率(HR)均降低,联合组患者T2~T4的HR比较无差异(P>0.05);右美托咪定组、联合组患者T2~T4的HR均高于对照组,且联合组高于右美托咪定组(P<0.05);对照组、右美托咪定组患者T4至拔管后60 min(T6)的镇静Ramsay评分与T3比较差异显著(P<0.05),联合组患者T4~T6与T3比较无明显差异(P>0.05);联合组躁动发生率明显低于对照组和右美托咪定组(P<0.05)。结论右美托咪定联合达克罗宁胶浆用于行PCNL的肾功能不全患者,可显著减轻气管插管拔管时所带来的血流波动,同时可降低躁动发生率。 Objective To investigate the clinical application of dexmedetomidine combined with Dyclonine Hydrochloride Mucilage in percutaneous nephrolithotomy(PCNL)for patients with renal insufficiency.Methods Totally 80 patients with renal insufficiency underwent PCNL from January 2013 to August 2017 in Dujiangyan People's Hospital were selected and divided into the control group(n=26),the dexmedetomidine group(n=27)and the combined group(n=27)according to the random number table method.During operation,the patients in the control group were given 0.9%Sodium Chloride Injection,the patients in the dexmedetomidine group were given Dexmedetomidine Hydrochloride Injection,and the patients in the combined group were given Dexmedetomidine Hydrochloride Injection combined with Dyclonine Hydrochloride Mucilage.Results Compared with those at entry(T1),the systolic blood pressure(SBP)and diastolic blood pressure(DBP)were increased in the control group at intubation(T2),extubation(T3)and 5 min after extubation(T4),while the SBP and DBP were decreased in the dexmedetomidine group at T2-T4(P>0.05),there was no difference in SBP and DBP in the combined group at T2-T4(P<0.05).The SBP and DBP in the dexmedetomidine group and the combined group were lower than those in the control group at T2-T4,while those in the combined group were higher than those in the dexmedetomidine group(P<0.05).Compared with that at T1,the heart rate(HR)in the control group and the dexmedetomidine group at T2-T4 was lower,but there was no difference in HR in the combined group at T2-T4 and T1(P>0.05),the HR in the dexmedetomidine group and the combined group was higher than that in the control group at T2-T4,and that in the combined group was higher than that in the dexmedetomidine group(P<0.05).The sedative Ramsay score of the control group and the dexmedetomidine group from T4 to 60 min after extubation(T6)was significantly different from that at T3(P<0.05).There was no significant difference in sedative Ramsay score between T4-T6 and T3 in the combined group(P
作者 王洪霞 唐华春 邓礼衡 WANG Hongxia;TANG Huachun;DENG Liheng(Dujiangyan Medical Center,Dujiangyan People's Hospital,Chengdu,Sichuan,China 611830)
出处 《中国药业》 CAS 2019年第15期47-49,共3页 China Pharmaceuticals
基金 四川省成都市卫生和计划生育委员会医学科研课题[20150062]
关键词 右美托咪定 达克罗宁胶浆 肾功能不全 经皮肾镜取石术 血流动力学 dexmedetomidine Dyclonine Hydrochloride Mucilage renal insufficiency percutaneous nephrolithotomy hemodynamics
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