摘要
CD109是细胞的一种表面抗原,通过TGF-β信号通路传导来调控细胞的增殖与分化,CD109还同时参与JAK-STAT和表皮生长因子受体(EGFR)信号通路调节细胞增殖与分化功能,与一些疾病及肿瘤的发生与发展密切相关。近年来研究发现CD109在基底细胞样乳腺癌中呈明显高表达,并且与基底细胞样乳腺癌易复发及转移相关,导致治疗和预后效果差。因此CD109检测分析对乳腺癌的诊断及治疗具有重要意义,CD109与乳腺癌的关系成为当前研究的热点。本文综述了CD109的生物学功能及CD109与乳腺癌的关系。
CD109 is a cell surface antigen that regulates cell proliferation and differentiation by negatively regulating TGF-β signaling pathway. It also participates in JAK-STAT and EGFR signaling pathways to regulate cell functions of proliferation and differentiation. It is closely related to the occurrence and development of some diseases and malignant tumors. In recent years, the CD109 has been found to be highly expressed in basal-like breast cancer. The treatment is not satisfying because of the recurrence and metastasis of the basal-like breast cancer. Thus the detection and analysis of CD109 on tumors is very important for the diagnosis and treatment of breast cancer, and the relationship between CD109 and breast cancer has become a hot topic of current research. This review focuses on the biological functions of CD109 and the relationship between CD109 and breast cancer.
作者
张亚男
宋娜
徐丽
张学东
韩冬
李荣贵
韩发彬
Zhang Yanan;Song Na;Xu Li;Zhang Xuedong;Han Dong;Li Ronggui;Han Fabin(College of Life Sciences, Qingdao University, Qingdao 266071, China;The Institute for Tissue Engineering and Regenerative, Liaocheng University/Liaocheng People's Hospital, Liaocheng 252000, China;Shandong Meijia Sai Pei Biotechnology Co., Ltd. Jinan 250101, China)
出处
《中华细胞与干细胞杂志（电子版）》
2019年第3期182-187,共6页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
基金
山东省自然科学基金(ZR2019PC017)
关键词
CD109
信号通路
乳腺癌
细胞增殖
细胞分化
CD109
Signaling pathway
Breast cancer
Cell proliferation,cell differentiation
