摘要
目的探讨应用布托啡诺与芬太尼静脉自控镇痛的效果。方法将2016年11月-2017年11月某医院应用静脉自控镇痛的手术患者84例归入本项研究中,以所用静脉镇痛药物对患者进行分组,布托啡诺组、芬太尼组,每组均42例,统计2组术后各时间段疼痛评分、镇静评分,并记录镇痛过程中出现不良反应的情况。结果 2组术后各时间段内疼痛评分十分接近,其差异无统计学意义(P>0.05);0.5~12 h时间段中布托啡诺组镇静评分显著优于芬太尼组,差异有统计学意义(P<0.05);在24~48 h时间段中,2者镇静评分接近,差异无统计学意义(P>0.05);布托啡诺组总不良反应出现几率为7.14%(3/42);芬太尼组不良反应整体发生率为23.81%(10/42),差异有统计学意义(P<0.05)。结论布托啡诺与芬太尼在静脉自控镇痛中镇痛效果相差无几,但布托啡诺镇静性更强,用药更为安全,可考虑为临床首选用药。
Objective To explore the effect of intravenous analgesia with butorphanol and fentanyl.Methods From November 2016 to November 2017,84 patients undergoing intravenous analgesia in the hospital were divided into a butorphanol group and a fentanyl group with 42 cases in each group according to the difference of analgesic drugs used in the study.The pain scores and sedation scores were counted and the adverse reactions were recorded.Results The pain score was very similar during each time period after the operation in both groups(P> 0.05).The sedation score of the butorphanol group was significantly better than that of the fentanyl group during the period of 0.5-12 hours(P< 0.05).During the period of 24-48 hours,the sedative score in the butorphanol group was close to that of the fentanyl group(P> 0.05).The incidence of total adverse reactions in the butorphanol group was 7.14%(3/42),and the incidence of total adverse reactions in the fentanyl group was 23.81%(10/42),and there was a significant difference(P< 0.05).Conclusion The analgesic effects of butorphanol and fentanyl in patient-controlled intravenous analgesia are similar,but butorphanol is more sedative and safe.Therefore,butorphanol is the first choice for clinical use.
作者
牛洪章
NIU Hong-zhang(Luoyang Oriental Hospital, Luoyang 471003, Henan, China)
出处
《中国校医》
2019年第6期445-447,共3页
Chinese Journal of School Doctor
关键词
静脉自控镇痛
布托啡诺
芬太尼
patient-controlled intravenous analgesia
butorphanol
fentanyl
