摘要
提出一种低成本、可一次性使用的聚合物薄膜惯性微流控芯片,并探索了样品输入流量、粒子尺寸及流道截面尺寸对直流道内粒子惯性聚焦效果的影响机制.该聚合物薄膜芯片采用激光切割和热塑封的新型工艺实现快速、批量化制造.随着样品输入流量的增加,粒子聚焦效果逐渐优化,并在达到峰值后,随流量进一步增加而下滑;不同尺寸粒子在相同结构流道内的表现差异显著,粒子直径越大,其在惯性直流道内的聚焦效果越好;不同流道截面宽度的实验结果显示,截面宽度较小的流道结构更利于实现粒子的聚焦.研制的新型直流道聚合物薄膜惯性微流控芯片具有实现细胞等生物医学样品高效预处理的应用前景.
A low-cost polymer-film inertial microfluidic chip with a simple straight channel was proposed.The effects of sample flow rate,particle size and channel cross-sectional dimension on particle focusing were systematically explored.By using the method of laser cutting and thermoplastic sealing,the microfluidic chips can be quickly and massively produced.The experimental results show that the particle focusing performance gradually enhances with increasing sample flow rate and then deteriorates after reaching the peak point.There are significant differences in the performance of particles focusing when particle sizes are different.The large particles are found to have better focusing performance than the small particles.The experimental results of microchannel with different cross-sectional widths show that smaller width channel is more beneficial for particle focusing.The proposed inertial microfluidic chip can provide the prospect of efficient pretreatment for biomedical applications.
作者
蒋丰韬
项楠
倪中华
Jiang Fengtao;Xiang Nan;Ni Zhonghua(Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments,Southeast University,Nanjing 211189,China;School of Mechanical Engineering,Southeast University,Nanjing 211189,China)
出处
《东南大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2019年第4期736-741,共6页
Journal of Southeast University：Natural Science Edition
基金
国家自然科学基金资助项目(81727801,51875103,51775111)
江苏省自然科学基金资助项目(BK20150606)
江苏省“六大人才高峰”高层次人才资助项目(SWYY-005)
关键词
惯性微流控芯片
直流道
惯性聚焦
聚合物薄膜
inertial microfluidic chip
straight microchannel
inertial focusing
polymer film
