摘要
目的 探讨达英-35、炔诺酮和黄体酮治疗围绝经期异常子宫出血(AUB)患者的疗效及安全性.方法 将137例AUB患者随机分为达英-35组(A组,n=45)、炔诺酮组(B组,n=46)、黄体酮组(C组,n=46).3组患者均给予诊断性刮宫治疗,在此基础上,3组分别给予口服达英-35、炔诺酮、黄体酮进行治疗,连续治疗3个疗程.比较分析3组患者的临床疗效、子宫内膜和性激素水平变化、不良反应.结果 治疗结束后,A组总有效率为95.6%,显著高于C组(82.6%,χ^2=3.90,P<0.05).B组与A组、C组总有效率比较差异均无统计学意义(χ^2=0.19,2.58,P>0.05).治疗后,A组、B组子宫内膜厚度均较C组明显降低(P<0.05).A组、B组治疗后子宫内膜厚度比较差异均无统计学意义(P>0.05).治疗后,各组FSH,LH及E2水平均明显下降,A组、B组下降幅度明显高于C组(P<0.05).A组、B组治疗后性激素水平比较差异均无统计学意义(P>0.05).A组、B组、C组不良反应的发生率分别为11.1%,15.2%,17.4%,差异无统计学意义(χ^2=0.74,P>0.05).A组1a复发率为4.4%,显著低于C组复发率(17.4%,χ^2=3.98,P<0.05).结论 达英-35、炔诺酮治疗AUB具有更好的疗效与安全性,尤其是达英-35在缩短阴道流血时间、改善子宫内膜增生及内分泌环境、调节内分泌激素、减少复发等方面具有明显的优势.
Objective To explore the efficacy and safety of diane-35,norethinne and progestin in the treatment of patients with abnormal uterine bleeding(AUB ) during perimenopause.Method137 AUB patients were randomly divided into diane-35 group (Group A, n =45),norethindrone group (Group B, n =46) and progesterone group (Group C, n =46).All the patients were all given diagnostic curettage treatment.On this basis,patients in the three groups were given orally diane-35,norethinne and progestin respectively for three consecutive treatment courses.The clinical efficacy,changes of endometrium and sex hormone levels and adverse reactions of three groups were compared and analyzed. Results After treatment,the total effective rate of Group A was 95.6%,significantly higher than that of Group C (82.6%,χ^2 =3.90, P <0.05).There was no significant difference in the total effective rate among Group B,Group A,Group C (χ^2 =0.19,2.58, P >0.05).After treatment,endometrial thickness in Group A and Group B was significantly lower than that in Group C ( P <0.05).There was no significant difference in endometrial thickness between Group A and Group B after treatment ( P >0.05).After treatment,the levels of FSH,LH and E2 in each group decreased significantly,and the decreased levels in Group A and Group B were significantly higher than those in Group C ( P <0.05).After treatment,there was no significant difference on sex hormone levels between Group A and Group B ( P >0.05).There was no significant difference,the incidence of adverse reactions in Group A,Group B and Group C was11.1%,15.2%, 17.4%,respectively,with no statistical significance (χ^2 =0.74, P >0.05).1-year recurrence rate of Group A was 4.4%, significantly lower than that of Group C (17.4%,χ^2 =3.98, P <0.05). Conclusions Diane-35 and norethinne have better efficacy and safety in the treatment of AUB,especially diane-35 has obvious advantages in shortening the time of vaginal bleeding,improving endometrial hyperplasia and endocrine environment,regulating endocrine hormones and r
作者
陈艳琴
黄凌云
顾燕芳
赵绍杰
Chen Yanqin;Huang Lingyun;Gu Yanfang;Zhao Shaojie(Wuxi Maternal and Child Health Hospital,Nanjing Medical University,Wuxi 214002,China)
出处
《北华大学学报（自然科学版）》
CAS
2019年第4期502-505,共4页
Journal of Beihua University（Natural Science）
基金
江苏省妇幼健康面上项目(F201827)
无锡市科教强卫医学发展学科建设对象项目(ZDXKJS001)
关键词
异常子宫出血
围绝经期
达英-35
炔诺酮
黄体酮
abnormal uterine bleeding
perimenopause
Diane-35
norethindrone
progesterone
