摘要
目的观察血必净注射液对急性百草枯中毒患者C反应蛋白(CRP)和肿瘤坏死因子α(TNF-α)的影响及其疗效分析。方法选取急性百草枯中毒患者92例,随机分为对照组和观察组,每组46例。对照组给予血液灌流、甲泼尼龙和环磷酰胺等常规治疗,观察组在对照组的基础上加用血必净注射液治疗。比较两组患者的CRP、TNF-α、白细胞计数(WBC)、血氧饱和度(SaO2)、氧合指数(PaO2/FiO2)和存活率等。结果治疗后第3、7、14天,观察组的WBC、CRP和TNF-α均低于对照组(均P<0.05),SaO2和PaO2/FiO2好转程度明显优于对照组(均P<0.05)。对照组和观察组的存活率分别为50.0%(23/46)和69.6%(32/46),差异无统计学意义(P>0.05)。结论血必净注射液可有效降低急性百草枯中毒患者血清CRP和TNF-α水平,减轻炎症反应,改善动脉血气指标水平,减少肺损伤。
Objective To investigate the effect of Xuebijing injection on CRP and TNF-α in patients with acute paraquat poisoning and its clinical significance. Methods A total of 92 patients with acute paraquat poisoning admitted to our hospital were selected as subjects and randomly divided into the Control Group and Treatment Group, 46 patients in each group. The Control Group was given routine treatment hemoperfusion, methylprednisolone and cyclophosphamide while the Treatment Group was administered with Xuebijing injection on the basis of the treatment for the Control Group. The CRP, TNF-α level, WBC, SaO2, PaO2/FiO2 and survival rate of the two groups were compared. Results The WBC, CRP and TNF-α in the Treatment Group were lower than those in the Control Group on Day 3, 7 and 14 after the treatment (P<0.05), and the improvement of SaO2 and PaO2/FiO2 in the Treatment Group were all superior to the Control Group (P<0.05). The survival rate of the Control Group was 50%(23/46) while that of the Treatment Group was 69.6%(32/46), and there was no significant difference between the two groups (P>0.05). Conclusion Xuebijing injection can effectively reduce serum CRP and TNF-α level in the patients with acute paraquat poisoning, reduce inflammation, improve arterial blood gas index and reduce lung injury.
作者
姚为学
李志文
陈粤明
苏耿
黄舒伟
YAO Wei-xue;LI Zhi-wen;CHEN Yue-ming;SU Geng;HUANG Shu-wei(The Central people's Hospital of Zhanjiang,Zhanjiang 524045, China)
出处
《广东医科大学学报》
2019年第4期398-400,共3页
Journal of Guangdong Medical University
关键词
百草枯
中毒
炎症
肺损伤
paraquat
poisoning
inflammation
lung injury
