摘要
目的探讨血清镁离子(Mg^2+)与慢性阻塞性肺疾病急性加重(AECOPD)次数及生活质量的相关性.方法前瞻性选取2016年1~12月因AECOPD而住院的病人117例,对所有病人行血常规、全血生化、动脉血气分析、肺功能及COPD评估测试(CAT)问卷检测.病人随访1年,统计其AECOPD次数及1年后CAT评分,分析血清Mg^2+水平与AECOPD次数及病人生活质量的相关性.结果病人1年内平均加重次数为1.00(0.25,1.00)次,频繁急性加重(AECOPD>2次/年)病人血清Mg^2+水平为(0.72±0.08)mmol/L,明显低于非频繁加重(AE-COPD≤2次/年)病人的(0.91±0.07)mmol/L,差异有统计学意义(P<0.001).Spearman相关分析显示,血清Mg^2+水平与AECOPD次数及1年后CAT评分呈负相关(r=-0.828、-0.737,P<0.001).Logistic回归分析显示,初次就诊CAT评分(OR=1.464,95%CI:1.060~2.022)及血清Mg^2+水平(OR=0.341,95%CI:0.121~0.683)是AECOPD的主要影响因素.结论血清Mg^2+与AECOPD次数及病人生活质量明显相关,是预测AECOPD及评价其生活质量的良好指标.
Objective To explore the correlation between serum magnesium and the frequency of acute exacerbation and quality of life in the patients with chronic obstructive pulmonary disease(COPD).Methods A total of 117 patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) admitted in our hospital from January 2016 to December 2016 were chosen prospectively.The complete blood routine index,biochemical profile,arterial blood gas analysis,pulmonary function were detected and COPD assessment test(CAT) was performed in all patients.All the patients were followed up for 1 year,the frequency of AECOPD and CAT score were recorded,and the relationship of serum magnesium with the frequency of AECOPD and CAT score was analyzed.Results The mean number of AECOPD was 1.00(0.25,1.00).The serum level of magnesium in frequent AECOPD patients was lower than that in non-frequent AECOPD patients(0.72 ± 0.08 mmol/L vs 0.91 ± 0.07 mmol/L,P<0.001).The serum magnesium was negatively correlated with the frequency of AECOPD and CAT score(r=-0.828,-0.737,P<0.001).Logistic regression analysis showed that the initial CAT score(OR=1.464,95%CI:1.060-2.022) and serum magnesium(OR=0.341,95%CI:0.121-0.683)were the main influencing factors of frequent AECOPD.Conclusions Serum magnesium has a significantly correlation with the frequency of AECOPD and quality of life in the patients with COPD,and it can be a good indicator for predicting AECOPD and evaluating the quality of life.
作者
陈锋
乜庆荣
韩雪峰
赵珊
张磊
CHEN Feng;NIE Qing-rong;HAN Xuefeng;ZHAO Shan;ZHANG Lei(Department of Respiratory and Critical Care Medcine,Liangxiang Teaching Hospital of Capital Medical University,Beijing 102401, China)
出处
《实用老年医学》
CAS
2019年第7期653-656,共4页
Practical Geriatrics
关键词
血清镁离子
慢性阻塞性肺疾病
急性加重
生活质量
serum magnesium
chronic obstructive pulmonary disease
acute exacerbation
quality of life
