摘要
精卵融合是受精过程中最为重要的步骤。目前公认IZUMO1、JUNO和CD9(cluster of differentiation antigen 9)为精卵融合的必需蛋白质,其中IZUMO1与JUNO在精卵识别时会形成复合体。有研究表明IZUMO1、JUNO和CD9主要参与精卵融合最初的黏附过程,且它们之间是相互关联发挥作用的。近年来由于X射线晶体学相关技术的发展,IZUMO1-JUNO晶体结构基本被阐明,然而精卵融合的具体分子机制仍未被完全揭示。所以,对哺乳动物精卵融合必需蛋白质IZUMO1-JUNO/CD9的结构、功能和分子机制进行阐述是十分必要的。
Sperm-egg fusion is the most important step in the process of fertilization.IZUMO1,JUNO and cluster of differentiation antigen 9(CD9)are currently recognized as essential proteins for sperm-egg fusion.IZUMO1 and JUNO form a complex when the sperm is recognized.Studies have shown that IZUMO1,JUNO and CD9 are mainly involved in the initial adhesion process of sperm-egg fusion,and they are interrelated.In recent years,the crystal structure of IZUMO1-JUNO has been basically elucidated with the development of X-ray crystallography.However,the specific molecular mechanism of sperm-egg fusion has not been fully revealed.Therefore,it is necessary that the structure,function and molecular mechanism of the essential proteins IZUMO1-JUNO/CD9 involved in the mammalian sperm-egg fusion should be elaborated.
作者
张英楠
黄佳星
梁欣然
李芽
于书海
王郑
ZHANG Ying-nan;HUANG Jia-xing;LIANG Xin-ran;LI Ya;YU Shu-hai;WANG Zheng(College of Life Sciences,Inner Mongolia University,Hohhot 010021,Inner Mongolia,China)
出处
《生命科学研究》
CAS
CSCD
2019年第3期226-230,共5页
Life Science Research
基金
内蒙古自然科学基金资助项目(2016MS0329)
内蒙古大学本科创新基金项目(201614241)
