摘要
目的探讨额叶癫痫(frontal lobe epilepsy,FLE)患者工作记忆障碍的脑电网络连接机制。方法招募17例成人FLE患者为病例组和与之匹配的正常成人22例为对照组,记录两组受试进行工作记忆行为学范式时的行为学数据和34通道脑电。应用定向传递函数构建工作记忆延迟期theta频段因果连接脑网络,使用双样本t或t'检验分析两组的行为学和额区因果连接脑网络差异。结果(1)FLE组和对照组工作记忆行为学比较:正确率降低[(92.778±4.399)%,(96.258±2.470)%,t'=-2.925,P<0.01],反应时间增加[(978.586±65.161)ms,(798.671±196.207)ms,t'=4.023,P<0.001]。(2)FLE组和对照组因果连接比较:全脑降低(t'=-6.008,P<0.001)、Fz通道降低(t'=-7.703,P<0.001)、额区内降低(t'=-14.667,P<0.001)、额-颞区间降低(t=-14.467,P<0.001)、额-中央区间降低(t=-3.501,P<0.001)。额-枕区间差异无统计学意义(t=1.056,P=0.281)。结论FLE患者存在明显工作记忆障碍,额区theta频段因果连接脑网络异常可能是其潜在神经生理机制之一。
Objective To investigate the possible electroencephalograph network connectivity mechanism of working memory disorder in patients with frontal lobe epilepsy (FLE). Methods Seventeen adult FLE patients were enrolled as the case group and 22 normal adults were selected as the control group.The behavioral data and 34-channel electroencephalographs were recorded in the working memory behavioral paradigm.The directed transfer function was used to construct the causal connectivity brain network of theta band of working memory delay period.Two-sample t-test or tˊ-test was used to analyze the differences in behavioral and frontal causal connectivity between the two groups. Results (1) Compared with control group, working memory behavioral data of FLE group showed significantly lower correct rate ((92.778±4.399)%,(96.258±2.470)%, tˊ=-2.925, P<0.01), and significantly longer reaction time ((978.586±65.161)ms,(798.671±196.207)ms, tˊ=4.023, P<0.001).(2) Compared with control group, causal connectivity of FLE group showed significantly reduced whole brain (tˊ=-6.008, P<0.001), Fz channel (tˊ=-7.703, P<0.001), frontal region (tˊ=-14.667, P<0.001), frontal-temporal interval (t=-14.467, P<0.001), and frontal-central interval (t=-3.501, P<0.001). The causal connectivity of frontal-occipital interval had no significant difference(t=1.056, P=0.281). Conclusions Working memory disorders were found in FLE patients.The abnormal causal connectivity of frontal brain network in theta band may be one of its potential neurophysiological mechanisms.
作者
鲍杰
宋毅军
潘立平
朱婧
Bao Jie;Song Yijun;Pan Liping;Zhu Jing(Department of Neurology, General Hospital of Tianjin Medical University, Tianjin 300052, China;Tianjin Institute of Neurology, Tianjin 300052, China;Department of Neurology, Linfen Central Hospital, Linfen 041000, China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2019年第6期527-531,共5页
Chinese Journal of Behavioral Medicine and Brain Science
基金
天津市自然科学基金京津冀专项项目(18JCZDJC44800)
天津市"131"创新型人才团队项目.
关键词
额叶癫痫
脑电
工作记忆障碍
定向传递函数
因果连接
脑网络
Frontal lobe epilepsy
Electroencephalograph
Working memory disorder
Directed transfer function
Causal connectivity
Brain network
