摘要
建立了一种实用的氧化芳烃侧链制备芳香族醛、酮的方法.以过硫酸钠为氧化剂,在氯化镍催化下,甲苯类底物的苄位发生氧化反应,得到芳香醛,收率为22%~79%.乙苯类底物更容易发生反应得到芳香酮,收率为64%~84%.苄基醇类底物的反应得到相应的羰基化合物,并显示出更快的反应速度和更高的选择性和收率.该反应条件温和,无需贵金属参与和额外的促进剂,选择性良好.
A practical method for the oxidation of aromatic side chains was established for the preparation of aromatic aldehydes and ketones.Using NiCl2 as the catalyst,substituted toluenes were oxidized with Na2S2O8 at the benzylic site for the synthesis of the corresponding aldehydes in the yield of 22%~79%.Ethylbenzene analogs were oxidized more easily to obtain the corresponding ketones with 64%~84%yields.The oxidation of benzyl alcohol analogs was completed to acquire the corresponding carbonyl compounds in shorter time with better selectivity and yields.The method has the advantages such as the mild reaction conditions,no requirement for precious metals or additional promoter,and good selectivity.
作者
刘立策
吴杰庆
马鸿飞
张晗
顾洁凡
李玉峰
Liu Lice;Wu Jieqing;Ma Hongfei;Zhang Han;Gu Jiefan;Li Yufenga(College of Chemistry and Molecular Engineering,Nanjing Tech University,Nanjing 210036;Nanjing UNOCI Chemical Co.,Nanjing 210009)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2019年第6期1688-1694,共7页
Chinese Journal of Organic Chemistry
关键词
氧化
芳烃
苄醇
氯化镍
过硫酸钠
oxidation
aromatic hydrocarbon
benzyl alcohol
nickel chloride
sodium persulfate
