摘要
目的探讨K-ras、PIK3CA基因突变与结直肠癌患者临床特征的关系,分析K-ras、PIK3CA基因表达的相关性。方法选取110例结直肠癌患者,均接受了K-ras、PIK3CA基因突变检测。分析结直肠癌患者的K-ras、PIK3CA基因突变情况,并比较不同临床特征的结直肠癌患者K-ras、PIK3CA基因的突变率,分析K-ras、PIK3CA基因表达的相关性。结果结直肠癌患者K-ras基因突变率为37.27%,PIK3CA基因突变率为18.18%;肿瘤直径≥5cm、直肠癌和Ⅲ~Ⅳ期患者K-ras基因突变率分别明显高于肿瘤直径﹤5cm、结肠癌和Ⅰ~Ⅱ期的患者(P﹤0.01);Ⅲ~Ⅳ期患者的PIK3CA基因突变率明显高于Ⅰ~Ⅱ期的患者(P﹤0.01);K-ras基因与PIK3CA基因表达呈正相关(r=0.514,P﹤0.01)。结论K-ras、PIK3CA基因突变与结直肠癌患者的临床特征有关,K-ras、PIK3CA基因表达有一定的相关性。
Objective To investigate the relationship between the mutation of K-ras and PIK3CA gene and the clinical characteristics of colorectal cancer, and to analyze the correlation between K-ras and PIK3CA gene mutation. Method All the 110 patients with colorectal cancer were tested for mutation of K-ras and PIK3CA gene mutation, which were further analyzed to compare the gene mutation rate of K-ras and PIK3CA among patients with varying clinical characteristics, the correlation between K-ras and PIK3CA gene expression was investigated. Result The mutation rate of K-ras gene was 37.27% in colorectal cancer patients, and the mutation rate of PIK3CA gene was 18.18%;the mutation rate of Kras gene in patients with tumor diameter ≥ 5 cm, rectal cancer and stage Ⅲ-Ⅳ disease was significantly higher than those in patients with tumor diameter < 5 cm, colon cancer and stage Ⅰ-Ⅱdisease(P<0.01);besides, the mutation rate of PIK3CA gene in stage Ⅲ-Ⅳ disease was significantly higher than that in stage Ⅰ-Ⅱ disease(P<0.01);K-ras gene was positively correlated with PIK3CA gene expression(r=0.514, P<0.01). Conclusion K-ras and PIK3CA gene mutations are related to the clinical characteristics of colorectal cancer, and they are correlated with each other.
作者
刘鑫
赵任
LIU Xin;ZHAO Ren(Department of General Surgery,Ruijin Hospital North Branch,School of Medicine,Shanghai Jiao Tong University,Shanghai 201801,China)
出处
《癌症进展》
2019年第13期1579-1582,共4页
Oncology Progress
