摘要
目的:分析重度慢性肝炎肝纤维化患者血清凝血酶原活动度(serum prothrombin activity,PTA)及其预后相关影响因素,为重度慢性肝炎肝纤维化患者个性化诊疗方案的制定提供参考依据。方法:收集122例重症肝炎合并肝纤维化患者的临床、影像学及流行病学资料,并对所有入选患者进行随访观察其预后状况。PTA检测采用SysmexCA-1500全自动血凝仪。结果:所有患者均获得完整随访,平均随访时间(27.14±11.73)个月;年龄、性别、身体质量指数(body mass index,BMI)、职业、医疗保险情况、吸烟量、酒精摄入量、是否有出血倾向、是否腹水、是否性功能减退、家族史、红细胞计量、白蛋白计量及血尿酸水平是影响患者PTA水平的因素;不同水平PTA患者的生存时间比较,差异有统计学意义(χ^2=16.627,P<0.001)。结论:重度慢性肝炎肝纤维化患者PTA可作为监测其预后状况的评估指标之一,高水平PTA患者的预后情况较好,低水平PTA患者的预后情况较差。
Objective:To quantitatively analyze serum prothrombin activity (PTA) in patients with severe chronic hepatitis and fibrosis,and to analyze the prognostic factors,and to provide a personalized diagnosis and treatment plan for patients with severe chronic hepatitis and liver fibrosis.Methods:The clinical data,imaging data and epidemiological data were collected.All patients were followed up to observe the prognosis.Sysmex CA-1500 automatic blood coagulation instrument was used to detect PTA.Results:A total of 122 valid subjects were enrolled in the study.All patients were followed up for an average of 27.14±11.73 months.Age,gender,BMI,occupation,medical insurance,smoking,alcohol intake,bleeding tendency,ascites,sexual dysfunction,family history,red blood cell count,albumin measurement,and serum uric acid levels were factors influencing patients' PTA levels ( P <0.05).There was a statistically significant difference in survival time between patients with different levels of PTA (χ^2=16.627, P <0.001).Conclusion:PTA in patients with severe chronic hepatitis and liver fibrosis can be used as one of the evaluation indicators for monitoring the prognosis.The prognosis of patients with high-level PTA is better,and the prognosis of patients with low-level PTA is worse.
作者
王超秀
陈炘
刘发彬
夏旭辉
WANG Chao-xiu;CHEN Xin;LIU Fa-bin;XIA Xu-hui(Department of Infectious Diseases,The First People's Hospital of Neijiang,Neijiang 641000,Sichuan,China)
出处
《川北医学院学报》
CAS
2019年第3期441-444,共4页
Journal of North Sichuan Medical College
