摘要
目的:观察魔芋降脂方对肥胖小鼠体质量以及血脂的影响。方法:60只雌雄各半KM小鼠,对照组16只小鼠普通饲料喂养12周,其余44只小鼠作为造模组高脂饲料喂养12周,根据血清甘油三脂(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平及体质量判断肥胖模型是否建立成功,将造模成功的小鼠分为模型组及魔芋降脂方低、中、高剂量组,魔芋降脂方各剂量组灌胃给药,每日1次,连续4周,模型组及对照组给予等量蒸馏水灌胃;观察干预前后各组小鼠的体质量,眼眶及心脏取血检测血清TC、TG、LDL-C及HDL-C水平。结果:造模小鼠进行12周高脂饲料喂养后,造模组小鼠的体质量、TC、TG、HDL-C高于对照组(P<0.01),体质量变化大于对照组(P<0.01),表明模型建立成功;与模型组相比,魔芋降脂方各剂量组小鼠体质量及血清TC、TG及LDL-C水平明显降低(P<0.01);与低剂量组相比,中剂量组及高剂量组小鼠的体质量及血清TC、TG、LDL-C水平明显下降(P<0.05);与中剂量组相比,高剂量组小鼠的体质量及血清TC、TG、LDL-C水平差异无统计学意义(P>0.05)。结论:魔芋降脂方具有明显的降低血脂及减轻体质量的作用。
Objective: To observe the effect of Konjac lipid-lowering recipe on body weight and blood lipids in obese mice,and to provide theoretical basis for the development of natural weight loss products made by hypolipidemic drugs like Konjac. Methods: Sixty KM mice,half male and half female,were randomly divided into 5 groups: the blank group,the model group,the low-dose group,the medium-dose group,and the high-dose group.Each group was intragastrically administered with Konjac lipid-lowering recipe once a day.4 weeks later,the body weight of each group was observed and serum was taken for blood triglyceride (TG),total cholesterol (TC),low density lipoprotein cholesterol (LDL-C),and high density lipoprotein cholesterol (HDL -C). Results: Compared with the model group,the body weight of each dose group was significantly lower,and the TG of all dose groups was lower,and the difference was significant ( P <0.01);the TC and LDL-C decreased significantly in each dose group ( P <0.01).And HDL-C was not significantly lower than that in the normal control group.Compared with the low-dose group,the body weight changes and blood lipids in the middle-dose and high-dose groups decreased significantly ( P <0.05).There was no obvious difference in body weight and blood lipids between the high-dose group and the middle-dose group ( P >0.05). Conclusion: Konjac lipid-lowering recipe has obvious effects of lowering blood lipids and reducing body weight.
作者
黄明琦
张晓
鲍佳志
罗雄
孙静
黄世祥
HUANG Mingqi;ZHANG Xiao;BAO Jiazhi;LUO Xiong;SUN Jing;HUANG Shixiang(School of Public Health,Guizhou Medical University,Guiyang 550025,Guizhou,China;The Affiliated Hospital ofGuizhou Medical University,Guiyang 550004,Guizhou,China;Innovation and Industrial Development Branch,Guizhou Medical University,Guiyang 550025,Guizhou,China;Academic Affairs Office,Guizhou Medical University,Guiyang 550025,Guizhou,China)
出处
《贵州医科大学学报》
CAS
2019年第6期680-683,共4页
Journal of Guizhou Medical University
基金
贵州省2017年国家级、省级大学生创新创业训练计划项目(201710660002)
关键词
魔芋降脂方
单纯性肥胖
体质量
血脂异常
小鼠
Konjac lipid-lowering recipe
simple obesity
body weight
blood lipid abnormality
mice
