摘要
淋巴管存在于人体大多组织中,并且在许多功能中起重要作用.随着淋巴管特异性标记物的发现,如VEGF-C/D/VEGFR-3、LYVE-1、Prox-1等,淋巴分子生物学的研究有了极大的进展.近来在结膜、角膜缘、泪腺和眼外肌中发现了淋巴管,而正常角膜中不存在淋巴管.虽然VEGF-C能诱导Schlemm管的生长并使眼压降低,但Schlemm管中淋巴管标记物表达谱不完整,不能被视为完整的淋巴管.脉络膜中无淋巴管,由LYVE-1(+)或CD34(+)/VEGFR-3(+)细胞构成的网状结构可能在炎症中暂时形成淋巴管通道.视神经和视网膜中虽无淋巴管,但可能存在水通道蛋白驱动的类淋巴途径.眼部淋巴管与眼部疾病密切相关,它们可能参与眼表炎症的发生发展,有助于青光眼患者的房水流出,而淋巴管功能障碍可能推动了老年性黄斑变性的进展.
The lymphatic network penetrates most tissues in the body and plays critical roles in man-y functions. The identification of specific markers for the lymphatic vessels, such as VEGF-C/D/VEGFR-3,LYVE-1, Prox-1, has been instrumental in the advance of lymphatic biology. People have found that con-junctiva, corneal limbus, lacrimal gland and extraocular muscles contain lymphatic vessels, while the normal corneal is devoid of lymphatic vessels. Although, injection of intraocular VEGF-C can increase sprouting and proliferation of schlemm' s canal ( SC) endothelial cells ( ECs) and reduce intraocular pressure,the lymphat-ic marker expression profile of SC is incomplete, which suggests that SC should not be considered as a fully differentiated lymphatic vessel. There is no lymphatic vessels in the choroid,but LYVE-1( +) or CD34( +)/ VEGFR-3( +) netlike structures may compose lymphatic vessels temporarily in inflammation. Retina and optic nerves are absent of lymphatics, but may have"lymphtic" system consist of AQP4. Ocular lymphatics are closely related to ocular diseases. They may participate in the development of ocular surface inflammation and help the outflow of aqueous humor in patients with glaucoma. Lymphatic dysfunction may contribute to the progression of age-related macular degeneration.
作者
杨璐菲
于津津
陈养浩
武志峰
Yang Lufei;Yu Jinjin;Chen Yanghao;Wu Zhifeng(Department of Ophthalmology, The Affiliated Wuxi No. 2 People' s Hospital of Nanjing Medical University, Wuxi 214002, China)
出处
《国际眼科纵览》
2019年第3期183-188,共6页
International Review of Ophthalmology
基金
无锡市“十三五”科教强卫工程眼科临床医学中心项目(LCZX003).
关键词
眼部淋巴管
眼部疾病
淋巴管
ocular lymphatics
ocular disease
lymphatic vessels
