摘要
目的以卡拉胶、变性淀粉为主要原料,结合辅料制备植物软胶囊囊皮并进行性能测试。方法采用D-最优混料设计,通过改变各因素的质量制备植物软胶囊囊皮,使用响应面法对囊皮进行力学性能和水蒸气透过系数分析,并优化囊皮的最适配方。结果甘油与水保持一定量时,当κ-卡拉胶0.9 g,ι-卡拉胶10.5g,氧化淀粉1.636g,热处理淀粉16.964g时,由此制得囊皮的抗拉强度达到最大,杨氏模量、水蒸气透过系数达到最小,囊皮的性能最优。结论本实验为植物软胶囊代替动物明胶软胶囊奠定理论基础。
OBJECTIVE To develop plant-derived soft capsule shell with carrageenan, modified starch and investigate their properties. METHODS The plant-derived soft capsule shell was prepared by using D-optimal mixture design and changing the quality of each factor. The mechanical properties and water vapor permeability coefficient of capsule skin were analyzed by response surface methodology, and the optimum formulation of capsule shell was optimized. RESULTS When glycerol and water remain constant, under the optimized conditions, edible capsule shell consisting of κ-carrageenan 0.9 g,ι-carrageenan 10.5 g, oxidized starch 1.636 g and heat-treated starch 16.964 g showed the best properties of tensile strength, Young′s modulus and water vapor permeability. CONCLUSION This study lays theoretical foundation for replacing gelatin soft capsules with plant-derived soft capsules.
作者
李佳
陈皓玉
张文慧
张林波
LI Jia;CHEN Hao-yu;ZHANG Wen-hui;ZHANG Lin-bo(College of Life Science,Jilin Agricultural University,Changchun 130118,China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2019年第11期894-899,共6页
Chinese Pharmaceutical Journal
基金
吉林省教育厅“十三·五”科学技术项目资助(JJKH20170304KJ)
关键词
植物软胶囊
抗拉强度
杨氏模量
水蒸气透过系数
响应面分析
plant-derived soft capsule
tensile strength
Young's modulus
water vapor permeability
response surface analysis
