摘要
目的考察不同厂家生产羟丙甲纤维素的理化性质,并建立羟丙甲纤维素理化性质与缓释效果之间的联系,为其进一步合理应用提供理论依据。方法收集不同厂家羟丙甲纤维素,分别采用激光粒度分析仪、堆密度测量装置、扫描电镜、X射线衍射仪、气相色谱对其粒度分布、堆密度、物理形态、结晶性以及取代度进行表征,然后将不同厂家羟丙甲纤维素压制成缓释片,通过溶出曲线比较缓释效果。结果不同厂家生产羟丙甲纤维素在理化性质上存在一定的差异,具体表现在:粒径大小不同,堆密度大小不同,物理形状不相同,是否存在结晶峰以及羟丙氧基含量差异,并且理化性质的差异导致缓释效果的不同。结论研究羟丙甲纤维素的理化性质能更好地控制质量,促进其更为广泛的应用。
OBJECTIVE To investigate the physicochemical properties of hydroxypropyl methylcellulose(HPMC)produced by different manufacturers,and to establish a link between the physicochemical properties of HPMC and its sustained release effect,which can provides a theoretical basis for further rational application.METHODS The physicochemical properties of HPMC collected from different manufacturers,such as particle size distribution,bulk density,physical form,crystallinity and degree of substitution were characterized by laser particle size analyzer,bulk density measuring device,scanning electron microscope,X-ray diffractometer and gas chromatography,respectively.Then,the HPMC from different manufacturers were pressed into sustained release tablets,and the sustained release effect was compared by the dissolution curve.RESULTS The physicochemical properties of HPMC produced by different factories are different,which are manifested in different particle sizes,different bulk densities,different physical shapes,whether there are differences in crystallization peaks and the content of hydroxypropoxy groups,and the different physicochemical properties directly lead to the difference of sustained release effects.CONCLUSION The study of physicochemical properties of HPMC can better control its quality and use it more widely.
作者
朱玉苹
杨钊
张燕
周星彤
张帅华
ZHU Yu-ping;YANG Zhao;ZHANG Yan;ZHOU Xing-tong;ZHANG Shuai-hua(Department of Pharmaceutical Analysis,School of Pharmacy,Qingdao University,Qingdao 266021,China;Qingdao Institute for Food and Drug Control,Qingdao 266071,China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2019年第12期1018-1023,共6页
Chinese Pharmaceutical Journal
关键词
羟丙甲纤维素
理化性质
缓释效果
HPMC
physicochemical property
sustained release effect
