摘要
目的分析手足口病(hand foot and mouth disease, HFMD)伴发热性惊厥(febrile seizures, FS)的临床特点,研究HFMD伴发FS的影响因素。方法回顾性分析2018年6~9月首都医科大学附属北京佑安医院收治的184例HFMD患儿的临床资料,排除3例既往存在热性惊厥和癫痫史的患儿,共入选181例,其中男123例,女58例,根据是否伴发FS分为惊厥组(117例)和非惊厥组(64例),描述HFMD伴发FS患儿的临床特点,比较两组间年龄、性别、实验室指标的差异,对HFMD伴发FS进行单因素及多因素分析。结果单因素分析显示,两组年龄、血糖、血钠、血氯水平差异均有统计学意义(P<0.05),惊厥组年龄显著低于非惊厥组[(1.3±0.9)岁、(2.6±1.9)岁,P=0.000],血糖高于非惊厥组[(5.9±1.3)mmol/L、(4.7±0.9)mmol/L,P=0.000],血钠低于非惊厥组[(135.1±2.3)mmol/L、(138.1±2.1)mmol/L,P=0.000];多因素分析显示,年龄、高糖血症、低钠血症是HFMD伴发FS的独立危险因素,OR值分别为1.313(95%CI:1.003~1.718)、0.474(95%CI:0.328~0.683)、1.706(95%CI:1.361~2.137),P均<0.05。结论对于低钠血症、高糖血症、年龄较小的HFMD患儿,应警惕FS的发生,及时给予对症处理。
Objective To analyze the clinical characteristics and the influence factors of hand, foot and mouth disease(HFMD) with febrile seizures(FS). Methods A retrospective analysis was made of the clinical data of 184 children with HFMD admitted to Beijing Youan Hospital from June to September 2018. Three cases of FS and epilepsy were excluded. One hundred and eighty-one children were enrolled, including 123 males and 58 females. The patients were divided into two groups according to whether they had FS or not. The clinical characteristics of children with FS were described. The differences of age, gender and laboratory test indices between the two groups were compared, and the single and multiple factors influencing FS in children were analyzed. Results A total of 117 children in seizures group and 64 children in non-seizures group were collected. The univariate analysis showed that age, blood sugar, blood sodium and blood chlorine levels were significantly different between the two groups(all P<0.05). Age in seizures group was significantly lower than that in non-seizures group [(1.3 ± 0.9) years vs.(2.6 ± 1.9) years, P<0.05], blood sugar was higher than that in non-seizures group [(5.9 ± 1.3)mmol/L vs.(4.7±0.9) mmol/L, P<0.05] and blood sodium was lower than that in non-seizures group [(135.1±2.3) mmol/L vs.(138.1 ± 2.1) mmol/L, P<0.05]. Multivariate analysis showed that age, hyperglycemia and hyponatremia were independent risk factors for FS associated with HFMD, and their OR values were 1.313(95% CI:1.003-1.718), 0.474(95% CI:0.328-0.683), 1.706(95% CI:1.361-2.137) respectively(P<0.05). Conclusions For children of HFMD with hyponatremia, hyperglycemia and younger age, we should be alert to the occurrence of FS and give timely symptomatic treatment.
作者
李侗曾
吉杉
蔡妙甜
段忠辉
梁连春
Li Tongzeng;JiShan;Cai Miaotian;Duan Zhonghui;Liang Lianchun(Department of General Infection, Beijing Youan Hospital, Capital Medical University, Beijing 1 ()()()69, China)
出处
《北京医学》
CAS
2019年第6期487-490,共4页
Beijing Medical Journal
关键词
手足口病
热性惊厥
临床特点
影响因素
hand, foot and mouth disease (HFMD): febrile seizures (FS)
clinical characteristics
influence factor
