摘要
目的:探讨复方异丙托溴铵雾化吸入联合阿奇霉素在小儿支原体肺炎中的应用效果。方法:选择80例支原体肺炎患儿(均为首次感染者)为研究对象,按照随机数字表法分为观察组(n=40)和对照组(n=40),观察组患儿采用阿奇霉素+复方异丙托溴铵雾化吸入,对照组患儿仅采用阿奇霉素治疗,持续治疗1周后比较两组患儿临床疗效、气道功能指标及炎症因子变化情况。结果:观察组患儿治疗总有效率95.0%,对照组患儿治疗总有效率82.5%,差异有统计学意义(P<0.05);观察组患儿各临床症状缓解时间和住院时间均短于对照组,差异有统计学意义(P<0.05);观察组患儿各项气道功能指标优于对照组,炎症指标低于对照组,差异均有统计学意义(P<0.05);观察组发生1例(2.5%)不良反应,对照组发生2例(5%),差异无统计学意义(P>0.05)。结论:小儿支原体肺炎采用阿奇霉素联合复方异丙托溴铵雾化吸入治疗方案,可以显著缓解患儿呼吸道症状,减轻炎症反应,有效改善气道功能,具有较高安全性。
Objective: To investigate effects of Azithromycin combined with compound ipratropium bromide aerosol inhalation in children with Mycoplasma pneumonia. Methods: 80 children with mycoplasmal pneumonia (both first-infected) were selected and divided into observation group (n=40) and control group (n=40) according to the random number table method. The observation group received Azithromycin+ Compound ipratropium bromide and aerosol inhalation, while the control group was treated with Azithromycin only. After 1 week of continuous treatment, the clinical efficacy and the changes of the airway function indexes and inflammatory factors were compared between the two groups. Results: The total effective rates of the observation group and the control group were 95.0% and 82.5%, respectively, and the difference was statistically significant (P<0.05). The clinical symptom relief time and hospitalization time of the observation group were shorter than those of the control group, and the differences were statistically significant (P<0.05). The airway function indexes of the observation group were better than those of the control group, the inflammation index was lower than that of the control group, and the differences were statistically significant (P<0.05). One case (2.5%) of adverse reaction occurred in the observation group and 2 cases (5%) were in the control group, and the difference was not statistically significant (P>0.05). Conclusions: Azithromycin combined with compound ipratropium bromide aerosol inhalation in the children with Mycoplasma pneumonia can significantly alleviate the respiratory symptoms, reduce the inflammatory reactions, and improve the airway functi on with higher safety.
作者
王同迅
WANG Tongxun(Wolong Hospital of Nanyang, Nanyang 473000 Henan, China)
出处
《中国民康医学》
2019年第10期3-5,共3页
Medical Journal of Chinese People’s Health
关键词
小儿支原体肺炎
阿奇霉素
复方异丙托溴铵
雾化吸入
Mycoplasma pneumonia
Children
Azithromycin
Compound ipratropium bromide
Aerosol inhalation
